📄 Architecture of the SARS coronavirus prefusion spike

The emergence in 2003 of a new coronavirus (CoV) responsible for the atypical pneumonia termed severe acute respiratory syndrome (SARS) was a stark reminder that hitherto unknown viruses have the potential to cross species barriers to become new human pathogens. Here we describe the SARS-CoV 'spike' structure determined by single-particle cryo-EM, along with the docked atomic structures of the receptor-binding domain and prefusion core. © 2006 Nature Publishing Group.

keywords 🔗 severe acute (1373) 🔗 fusion core (19) 🔗 receptor-binding domain (99) 🔗 respiratory syndrome (2004) 🔗 acute respiratory (1734)

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