BACKGROUND: Currently, the epidemic of Coronavirus Disease 2019 (COVID-19) has begun to spread worldwide. We aim to explore reliable evidences for the diagnosis and treatment of the COVID-19 by analyzing all the published studies by Chinese scholars on the clinical and imaging features in novel coronavirus pneumonia (NCP) caused by SARS-CoV-2. METHODS: We searched five medical databases including two Chinese and three English databases for all published articles on COVID-19 since the outbreak. A random-effects model was designed, and the imaging and clinical data from all studies were collected for meta-analysis. RESULTS: Overall, 31 articles and 46959 patients were included, including 10 English articles, 21 Chinese articles. The results of meta-analysis showed that the most common clinical manifestations were fever (87.3%, 0.838-0.909), cough (58.1%, 0.502-0.660), dyspnea (38.3%, 0.246-0.520), muscle soreness or fatigue (35.5%, 0.253-0.456), chest distress (31.2%, -0.024-0.648). The main imaging finding were bilateral pneumonia (75.7%, 0.639-0.871), and ground glass opacification (69.9%, 0.602-0.796). Among the patients, the incidence of required intensive care unit (ICU) was (29.3%, 0.190-0.395), the incidence of acute respiratory distress syndrome (ARDS) was (28.8%, 0.147-0.429), the multiple organ dysfunction syndrome (MODS) was (8.5%, -0.008-0.179), and and the case fatality rate of patients with COVID-19 was (6.8%, 0.044-0.093). CONCLUSION: COVID-19 is a new clinical infectious disease, which mainly causes bilateral pneumonia, and lung function will deteriorate rapidly. Nearly a third of patients need to be admitted to the ICU, and patients are likely to cause respiratory failure or even death. This article is protected by copyright.
year ⏰ 2020
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