📄 Antibody avidity maturation during severe acute respiratory syndrome-associated coronavirus infection

The maturation of virus-specific immunoglobulin G avidity during severe acute respiratory syndrome-associated coronavirus infection was examined. The avidity indices were low (mean ± SD, 30.8% ± 11.6%) among serum samples collected ≤ 50 days after fever onset, intermediate (mean ± SD, 52.1% ± 14.1%) among samples collected between days 51 and 90, and high (mean ± SD, 78.1% ± 8.0%) among samples collected after day 90. Avidity indices of 40% and 55% could be considered as cutoff values for determination of recent (≤ 50 days) and past (>65 days) infection, respectively. Measurement of antibody avidity can be used to differentiate primary infection from reexposure and to assess humoral responses to candidate vaccines. © 2005 by the Infectious Diseases Society of America.

keywords 🔗 severe acute (1373) 🔗 serum samples (106) 🔗 samples collected (74) 🔗 respiratory syndrome-associated (90) 🔗 coronavirus infection (270) 🔗 respiratory syndrome (2004) 🔗 acute respiratory (1734) 🔗 syndrome-associated coronavirus (88)

download 🔖 [BibTeX]