📄 Protective effect of an inactivated avian coronavirus vaccine administered by aerosol

The antigenicity and protective effect of 3 strains of avian infectious bronchitis virus inactivated by beta-propiolactone were studied. Chickens administered 2 doses of the inactivated Connecticut strain (IBV-46) vaccine by aerosol at 3-week intervals had significant levels of virus-neutralizing antibodies and were resistant to infection by the Massachusetts strain (IBV-41) as determined by virus isolation attempts. Antibody levels in chickens given inactivated Iowa 33 and Iowa 609 were not significant and they were not resistant to infection by IBV-41.

keywords 🔗 bronchitis virus (233) 🔗 neutralizing antibodies (122) 🔗 avian infectious (53) 🔗 infectious bronchitis (235)

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