📄 Development, characterization, and application of monoclonal antibodies against severe acute respiratory syndrome coronavirus nucleocapsid protein

Five monoclonal antibodies (MAbs) against recombinant nucleocapsid protein (NP) of severe acute respiratory syndrome (SARS)-causing coronavirus (CoV) were developed by hybridoma technology. Epitope mapping by Western blotting showed that these anti-SARS-CoV NP MAbs bind to distinct domains of NP. These anti-SARS-CoV NP MAbs, with their high specificity, are potentially ideal candidates for developing early and sensitive diagnostic assays for SARS-CoV. Copyright © 2010, American Society for Microbiology.

keywords 🔗 severe acute (1373) 🔗 monoclonal antibodies (131) 🔗 nucleocapsid protein (162) 🔗 respiratory syndrome (2004) 🔗 acute respiratory (1734)

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