๐ A pantropic canine coronavirus genetically related to the prototype isolate CB/05
We report the genetic and biological characterisation of a novel pantropic canine coronavirus (CCoV), strain 450/07, which caused the death of a 60-day-old miniature pinscher. At the genetic level, this virus was strictly related to the prototype strain CB/05, but displayed some unique features. After experimental infection with the new pantropic isolate, most inoculated dogs showed diarrhoea and acute lymphopenia. Gross lesions and histological changes were mainly evident in the gut and lymphoid tissues, although some animals showed remarkable changed also in parenchymatous organs. The viral RNA was detected in the faeces and/or internal organs of most pups. These findings seem to indicate that strain 450/07 is able to spread to internal organs (mainly lymphoid tissues), causing lymphopenia but inducing a mild disease.
keywords
๐ canine coronavirus (102)
author
๐ค Decaro, Nicola
๐ค Mari, Viviana
๐ค von Reitzenstein, Marcela
๐ค Lucente, Maria Stella
๐ค Cirone, Francesco
๐ค Elia, Gabriella
๐ค Martella, Vito
๐ค King, Vickie L.
๐ค Di Bello, Antonio
๐ค Varello, Katia
๐ค Zhang, Shucheng
๐ค Caramelli, Maria
๐ค Buonavoglia, Canio
year
โฐ 2012
journal
๐ Veterinary Microbiology
issn
๐ 03781135 18732542
volume
159
number
1-2
page
239-244
citedbycount
10
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