BACKGROUND: Colchicine has been utilized safely in a variety of cardiovascular clinical conditions. Among its potential mechanisms of action is the non-selective inhibition of NLRP3 inflammasome which is thought to be a major pathophysiologic component in the clinical course of patients with COVID-19. METHODS: GRECCO-19 will be prospective, cluster randomized, open-labeled, controlled study. Patients with laboratory confirmed SARS-CoV-2 infection (under RT PCR) and clinical picture that involves temperature >37.5 oC and at least two out of the: i. sustained coughing, ii. sustained throat pain, iii. Anosmia and/or ageusia, iv. fatigue/tiredness, v. PaO2<95 mmHg will be included. CONCLUSIONS: GRECCO-19 trial aims to identify whether colchicine may positively intervene in the clinical course of COVID-19. (The study has been submitted to clinicaltrials.gov on March 26, 2020).
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author 👤 Deftereos, Spyridon G 👤 Siasos, Gerasimos 👤 Giannopoulos, Georgios 👤 Vrachatis, Dimitrios A 👤 Angelidis, Christos 👤 Giotaki, Sotiria G 👤 Gargalianos, Panagiotis 👤 Giamarellou, Helen 👤 Gogos, Charalampos 👤 Daikos, Georgios 👤 Lazanas, Marios 👤 Lagiou, Pagona 👤 Saroglou, Georgios 👤 Sipsas, Nikolaos 👤 Tsiodras, Sotirios 👤 Chatzigeorgiou, Dimitrios 👤 Moussas, Nikolaos 👤 Kotanidou, Anastasia 👤 Koulouris, Nikolaos 👤 Oikonomou, Evangelos 👤 Kaoukis, Andreas 👤 Kossyvakis, Charalampos 👤 Raisakis, Konstantinos 👤 Fountoulaki, Katerina 👤 Comis, Mihalis 👤 Tsiachris, Dimitrios 👤 Sarri, Eleni 👤 Theodorakis, Andreas 👤 Martinez-Dolz, Luis 👤 Jorge, Sanz-Sanchez 👤 Reimers, Bernhard 👤 Stefanini, Giulio G 👤 Cleman, Michael 👤 Filippou, Dimitrios 👤 Olympios, Christoforos D 👤 Pyrgakis, Vlasios N 👤 Goudevenos, John 👤 Hahalis, George 👤 Kolettis, Theofilos M 👤 Iliodromitis, Efstathios 👤 Tousoulis, Dimitrios 👤 Stefanadis, Christodoulos
year ⏰ 2020
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