📄 Programmed -1 ribosomal frameshifting in the SARS coronavirus

Programmed -1 ribosomal frameshifting is an alternate mechanism of translation used by coronavirus to synthesize replication proteins encoded by two overlapping open reading frames. For some coronaviruses, the mRNA cis-acting stimulatory structures involved in this process have been characterized, but their precise contribution to ribosomal frameshifting is not completely understood. Recently, a novel coronavirus was identified as the causative agent of the severe acute respiratory syndrome. This review describes the mRNA motifs involved in programmed -1 ribosomal frameshifting in this virus.

keywords 🔗 severe acute (1373) 🔗 reading frames (100) 🔗 reading frame (222) 🔗 causative agent (117) 🔗 ribosomal frameshifting (13) 🔗 novel coronavirus (684) 🔗 respiratory syndrome (2004) 🔗 acute respiratory (1734) 🔗 open reading (215)

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