📄 Human enteric coronaviruses: Antigenic relatedness to human coronavirus oc43 and possible etiologic role in viral gastroenteritis

In a group of infants with acute nonbacterial gastroenteritis, examination of paired sera for antibody to human coronavirus (HCV) OC43 and neonatal calf diarrhea coronavirus showed a peculiar pattern of serological response, restricted only to HCV OC43 surface antigens, in a significantly higher proportion than among age-matched controls. In another group of infants and young children with acute nonbacterial gastroenteritis, fecal excretion of coronavirus-like particles was detected by electron microscopy in 34 (16.3%) of 208 patients as compared with three (1.6%) of 182 controls (P <.01). Two strains of human enteric coronavirus (HECV) were purified from stools of two patients, and immune sera were raised in mice and guinea pigs. Immune electron microscopy showed a two-way cross-reactivity between HECV and HCV OC43 when tested with immune sera and convalescent-phase sera from patients with infection due to HECV or HCV OC43. © 1985 The University of Chicago.

keywords 🔗 significantly higher (104) 🔗 enteric coronavirus (111) 🔗 human coronavirus (623) 🔗 electron microscopy (149) 🔗 young children (25)

download 🔖 [BibTeX]