📄 Resolution of primary severe acute respiratory syndrome-associated coronavirus infection requires Stat1

Intranasal inhalation of the severe acute respiratory syndrome coronavirus (SARS CoV) in the immunocompetent mouse strain 129Sv. Ev resulted in infection of conducting airway epithelial cells followed by rapid clearance of virus from the tangs and the development of self-limited broachiolitis. Animals resistant to the effects of interferons by virtue of a deficiency in Stat1 demonstrated a markedly different course following intranasal inhalation of SARS CoV, one characterized by replication of virus an lungs and progressively worsening pulmonary disease with inflammation of small airways and alveoli and systemic spread of the virus to livers and spleens.

keywords 🔗 severe acute (1373) 🔗 syndrome coronavirus (1074) 🔗 respiratory syndrome (2004) 🔗 acute respiratory (1734) 🔗 epithelial cells (128)

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