📄 Severe acute respiratory syndrome coronavirus accessory protein 6 is a virion-associated protein and is released from 6 protein-expressing cells

Analysis of severe acute respiratory syndrome coronavirus (SCoV) by either sucrose gradient equilibrium centrifugation or a virus capture assay using an anti-SCoV S protein antibody demonstrated that the SCoV 6 protein, which is one of the accessory proteins of SCoV, was incorporated into virus particles. Coexpression of the SCoV S, M, E, and 6 proteins was sufficient for incorporation of the 6 protein into virus-like particles. Cells transfected with plasmid expressing the 6 protein released SCoV 6 protein; however, infected cells released SCoV 6 protein only in association with SCoV particles. Copyright © 2007, American Society for Microbiology.

keywords 🔗 severe acute (1373) 🔗 syndrome coronavirus (1074) 🔗 sucrose gradient (18) 🔗 infected cells (307) 🔗 respiratory syndrome (2004) 🔗 acute respiratory (1734) 🔗 accessory proteins (53)

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