📄 NMR assignments of the macro domain from Middle East respiratory syndrome coronavirus (MERS-CoV)

© 2016, Springer Science+Business Media Dordrecht. The newly emerging human pathogen, Middle East respiratory syndrome coronavirus (MERS-CoV), contains a macro domain in the highly conserved N-terminal region of non-structural protein 3. Intense research has shown that macro domains bind ADP-ribose and other derivatives, but it still remains intangible about their exact function. In this study we report the preliminary structural analysis through solution NMR spectroscopy of the MERS-CoV macro domain. The near complete NMR assignments of MERS-CoV macro domain provide the basis for subsequent structural and biochemical investigation in the context of protein function.

keywords 🔗 syndrome coronavirus (1074) 🔗 respiratory syndrome (2004) 🔗 highly conserved (80)

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