📄 SARS Coronavirus E protein in phospholipid bilayers: An X-ray study

We investigated the structure of the hydrophobic domain of the severe acute respiratory syndrome E protein in model lipid membranes by x-ray reflectivity and x-ray scattering. In particular, we used x-ray reflectivity to study the location of an iodine-labeled residue within the lipid bilayer. The label imposes spatial constraints on the protein topology. Experimental data taken as a function of protein/lipid ratio P/L and different swelling states support the hairpin conformation of severe acute respiratory syndrome E protein reported previously. Changes in the bilayer thickness and acyl-chain ordering are presented as a function of P/L, and discussed in view of different structural models. © 2006 by the Biophysical Society.

keywords 🔗 severe acute (1373) 🔗 respiratory syndrome (2004) 🔗 acute respiratory (1734)

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