📄 Systemic Coronavirus-associated disease in the domestic ferret (Mustela putorius): Histopathologic and immunohistochemical characterization in three ferrets Coronavirose systémique chez le furet (Mustela putorius) : intérêt de l'analyse histologique et immunohistochimique. À propos de trois cas

Background: A disease resembling feline infectious peritonitis (FIP) has been recognized recently in ferrets, mostly in United States and in Spain. This disease is due to a Group 1 Coronavirus, closely related to the ferret enteric Coronavirus. Objective: To demonstrate the viral origin of severe pyogranulomatous lymphoid and visceral lesions in three ferrets. Methods: Histopathology and immunohistochemistry of lesions received in our laboratory. Results: Severe pyogranulomatous inflammation was observed in the abdominal lymph nodes and in various organs. Positive labelling of Coronavirus antigen was demonstrated in macrophages in the pyogranulomatous lesions by immunohistochemistry. Conclusion: The three cases of severe pyogranulomatous disseminated inflammation were due to a Coronavirus, causing a systemic coronavirosis in ferret with a high similarity to FIP. © 2009 AFVAC.

keywords 🔗 closely related (222) 🔗 infectious peritonitis (181) 🔗 feline infectious (145) 🔗 lymph node (56)

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