📄 False-Negative Results of Real-Time Reverse-Transcriptase Polymerase Chain Reaction for Severe Acute Respiratory Syndrome Coronavirus 2: Role of Deep-Learning-Based CT Diagnosis and Insights from Two Cases.

The epidemic of 2019 novel coronavirus, later named as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is still gradually spreading worldwide. The nucleic acid test or genetic sequencing serves as the gold standard method for confirmation of infection, yet several recent studies have reported false-negative results of real-time reverse-transcriptase polymerase chain reaction (rRT-PCR). Here, we report two representative false-negative cases and discuss the supplementary role of clinical data with rRT-PCR, including laboratory examination results and computed tomography features. Coinfection with SARS-COV-2 and other viruses has been discussed as well.

keywords 🔗 *COVID-19 (1240) 🔗 *Computed tomography (55) 🔗 *False-negative results () 🔗 *Laboratory examination () 🔗 *SARS-COV-2 (551) 🔗 *rRT-PCR () 🔗 severe acute (1373) 🔗 syndrome coronavirus (1074) 🔗 polymerase chain (300) 🔗 novel coronavirus (684) 🔗 real-time reverse (87) 🔗 nucleic acid (139) 🔗 respiratory syndrome (2004) 🔗 acute respiratory (1734) 🔗 computed tomography (55) 🔗 chain reaction (303) 🔗 transcriptase polymerase (48)

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