The ecology of cytopathic expression of bovine coronavirus (BCV) in HRT‐18 cells was analyzed within virus‐induced plaques by scanning electron microscopy. Virus replication was cytocidal for many HRT‐18 cells, a function enhanced in the presence of trypsin. A monolayer of cells remained that imparted a characteristic turbidity to the plaque. These structurally normal, lysisresistant cells did not stain with fluorescent antibodies specific for BCV antigens, failed to adsorb virus particles or mouse erythrocytes in contrast to the susceptible cells. The survival of cells in the plaque interior reflects a non‐productively infected population with evidence of viral persistence. © 1990 Blackwell Verlag GmbH
year ⏰ 1990
issn 🗄 14390450 09311793
volume 37
number 1-10
page 501-508
citedbycount 7
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