๐ Middle east respiratory syndrome coronavirus spike protein delivered by modified vaccinia virus ankara efficiently induces virus-neutralizing antibodies
Middle East respiratory syndrome coronavirus (MERS-CoV) has recently emerged as a causative agent of severe respiratory disease in humans. Here, we constructed recombinant modified vaccinia virus Ankara (MVA) expressing full-length MERS-CoV spike (S) protein (MVA-MERS-S). The genetic stability and growth characteristics of MVA-MERS-S make it a suitable candidate vaccine for clinical testing. Vaccinated mice produced high levels of serum antibodies neutralizing MERS-CoV. Thus, MVAMERS- S may serve for further development of an emergency vaccine against MERS-CoV. ยฉ 2013, American Society for Microbiology.
keywords
๐ syndrome coronavirus (1074)
๐ causative agent (117)
๐ respiratory syndrome (2004)
author
๐ค Song, Fei
๐ค Fux, Robert
๐ค Provacia, Lisette B.
๐ค Volz, Asisa
๐ค Eickmann, Markus
๐ค Becker, Stephan
๐ค Osterhaus, Albert D.M.E.
๐ค Haagmans, Bart L.
๐ค Suttera, Gerd
year
โฐ 2013
journal
๐ Journal of Virology
issn
๐ 0022538X 10985514
volume
87
number
21
page
11950-11954
citedbycount
78
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