📄 Antiviral activity of itraconazole against type i feline coronavirus infection

Feline coronaviruses (FCo. Vs) are the causative agents of severe systemic disease (feline infectious peritonitis: FIP) in domestic and wild cats. FCo. Vs have been classified into serotypes I and II. Type I FCoV is the dominant serotype (approximately 70-90%) worldwide. Therefore, it is necessary to provide antiviral agents for type I FCoV infection. In this study, we demonstrated that itraconazole (ICZ), practically used for fungal infections in cats, inhibits the type I FCoV infection. ICZ also exhibited antiviral effect in cells after viral infection, suggesting that ICZ could potentially be used as a therapeutic.

keywords 🔗 causative agent (117) 🔗 infectious peritonitis (181) 🔗 feline infectious (145)

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