📄 Blocking of exchange proteins directly activated by cAMP leads to reduced replication of middle east respiratory syndrome coronavirus

The outbreak of Middle East respiratory syndrome coronavirus (MERS-CoV) infections and diseases represents a potential threat for worldwide spread and requires development of effective therapeutic strategies. In this study, we revealed a novel positive function of an exchange protein directly activated by cyclic AMP 1 (cAMP-1; Epac-1) on MERS-CoV replication. Specifically, we have shown that Epac-specific inhibitor treatment or silencing Epac-1 gene expression rendered cells resistant to viral infection. We believe Epac-1 inhibitors deserve further study as potential therapeutic agents for MERS-CoV infection.© 2014, American Society for Microbiology.

keywords 🔗 syndrome coronavirus (1074) 🔗 respiratory syndrome (2004)

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