๐ Nsp1 proteins of group I and SARS coronaviruses share structural and functional similarities
The nsp1 protein of the highly pathogenic SARS coronavirus suppresses host protein synthesis, including genes involved in the innate immune system. A bioinformatic analysis revealed that the nsp1 proteins of group I and SARS coronaviruses have similar structures. Nsp1 proteins of group I coronaviruses interacted with host ribosomal 40S subunit and did not inhibit IRF-3 activation. However, synthesis of host immune and non-immune proteins was inhibited by nsp1 proteins at both transcriptional and translational levels, similar to SARS coronavirus nsp1. These results indicate that different coronaviruses might employ the same nsp1 mechanism to antagonize host innate immunity and cell proliferation. However, nsp1 may not be the key determinant of viral pathogenicity, or the factor used by the SARS coronavirus to evade host innate immunity.
keywords
๐ highly pathogenic (100)
๐ innate immunity (35)
๐ innate immune (105)
๐ results indicate (178)
author
๐ค Wang, Yongjin
๐ค Shi, Huiling
๐ค Rigolet, Pascal
๐ค Wu, Nannan
๐ค Zhu, Lichen
๐ค Xi, Xu Guang
๐ค Vabret, Astrid
๐ค Wang, Xiaoming
๐ค Wang, Tianhou
year
โฐ 2010
issn
๐ 15671348
volume
10
number
7
page
919-924
citedbycount
16
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