📄 ORF8-related genetic evidence for Chinese horseshoe bats as the source of human severe acute respiratory syndrome coronavirus

© The Author 2015. Published by Oxford University Press for the Infectious Diseases Society of America. Several lineage B betacoronaviruses termed severe acute respiratory syndrome (SARS)-like Co. Vs (SL-Co. Vs) were identified from Rhinolophus bats in China. These viruses are characterized by a set of unique accessory open reading frames (ORFs) that are located between the M and N genes. Among unique accessory ORFs, ORF8 is most hypervariable. In this study, the ORF8s of all SL-Co. Vs were classified into 3 types, and, for the first time, it was found that very few SL-Co. Vs from Rhinolophus sinicus have ORF8s that are identical to that of human SARS-CoV. This finding provides new genetic evidence for Chinese horseshoe bats as the source of human SARS-CoV.

keywords 🔗 severe acute (1373) 🔗 reading frames (100) 🔗 reading frame (222) 🔗 respiratory syndrome (2004) 🔗 acute respiratory (1734) 🔗 open reading (215)

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