๐ Transcriptomic characteristics of bronchoalveolar lavage fluid and peripheral blood mononuclear cells in COVID-19 patients.
Circulating in China and 158 other countries and areas, the ongoing COVID-19 outbreak has caused devastating mortality and posed a great threat to public health. However, efforts to identify effectively supportive therapeutic drugs and treatments has been hampered by our limited understanding of host immune response for this fatal disease. To characterize the transcriptional signatures of host inflammatory response to SARS-CoV-2 (HCoV-19) infection, we carried out transcriptome sequencing of the RNAs isolated from the bronchoalveolar lavage fluid (BALF) and peripheral blood mononuclear cells (PBMC) specimens of COVID-19 patients. Our results reveal distinct host inflammatory cytokine profiles to SARS-CoV-2 infection in patients, and highlight the association between COVID-19 pathogenesis and excessive cytokine release such as CCL2/MCP-1, CXCL10/IP-10, CCL3/MIP-1A, and CCL4/MIP1B. Furthermore, SARS-CoV-2 induced activation of apoptosis and P53 signalling pathway in lymphocytes may be the cause of patients' lymphopenia. The transcriptome dataset of COVID-19 patients would be a valuable resource for clinical guidance on anti-inflammatory medication and understanding the molecular mechansims of host response.
keywords
๐ COVID-19 (1240)
๐ cytokine (205)
๐ inflammation (117)
๐ lymphopenia (40)
๐ transcriptome profiling ()
๐ public health (392)
๐ immune response (314)
๐ bronchoalveolar lavage (18)
author
๐ค Xiong, Yong
๐ค Liu, Yuan
๐ค Cao, Liu
๐ค Wang, Dehe
๐ค Guo, Ming
๐ค Jiang, Ao
๐ค Guo, Dong
๐ค Hu, Wenjia
๐ค Yang, Jiayi
๐ค Tang, Zhidong
๐ค Wu, Honglong
๐ค Lin, Yongquan
๐ค Zhang, Meiyuan
๐ค Zhang, Qi
๐ค Shi, Mang
๐ค Liu, Yingle
๐ค Zhou, Yu
๐ค Lan, Ke
๐ค Chen, Yu
year
โฐ 2020
journal
๐ Emerg Microbes Infect
issn
๐
volume
number
page
citedbycount
0
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