📄 Isolation and characterization of a novel bat coronavirus closely related to the direct progenitor of severe acute respiratory syndrome coronavirus

© 2016, American Society for Microbiology. Wereport the isolation and characterization of a novel bat coronavirus which is much closer to the severe acute respiratory syndrome coronavirus (SARS-CoV) in genomic sequence than others previously reported, particularly in its S gene. Cell entry and susceptibility studies indicated that this virus can use ACE2 as a receptor and infect animal and human cell lines. Our results provide further evidence of the bat origin of the SARS-CoV and highlight the likelihood of future bat coronavirus emergence in humans.

keywords 🔗 severe acute (1373) 🔗 syndrome coronavirus (1074) 🔗 cell lines (125) 🔗 respiratory syndrome (2004) 🔗 acute respiratory (1734) 🔗 cell line (211) 🔗 previously reported (79)

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