๐ Association between mannose-binding lectin gene polymorphisms and susceptibility to severe acute respiratory syndrome coronavirus infection
Background. Genetic determinants of susceptibility to severe acute respiratory syndrome coronavirus (SARS-CoV) infection remain unknown. We assessed whether mannose-binding lectin (MBL) gene polymorphisms were associated with susceptibility to SARS-CoV infection or disease severity in an ethnically homogeneous population born in northern China. Methods. The frequencies of 1 mutation in codon 54 and 3 promoter polymorphisms at nt -550, -221, and 4 were ascertained in 352 patients with SARS and 392 control subjects, by means of polymerase chain reaction direct sequencing. Results. Of 352 patients with SARS and 392 control subjects, 120 (34.4%) and 91 (23.2%) were carriers of the codon 54 variant, respectively (odds ratio [OR], 1.73 [95% confidence interval CI, 1.25-2.39]; P = .00086). A total of 123 (36.0%) of 352 patients with SARS and 100 (25.5%) of 392 control subjects had haplotype pairs associated with medium or low expression of MBL (OR, 1.67 [95% CI, 1.21-2.29]; P = .00187). The population-attributable fraction of patients with SARS that was associated with having the codon 54 variant was 20.1% (95% CI, 7.9%-32.3%). Conclusions. MBL gene polymorphisms were significantly associated with susceptibility to SARS-CoV infection; this might be explained by the reduced expression of functional MBL secondary to having the codon 54 variant. ยฉ 2005 by the Infectious Diseases Society of America.
keywords
๐ severe acute (1373)
๐ syndrome coronavirus (1074)
๐ odds ratio (31)
๐ polymerase chain (300)
๐ respiratory syndrome (2004)
๐ acute respiratory (1734)
๐ control subjects (13)
๐ confidence interval (64)
๐ chain reaction (303)
author
๐ค Zhang, Hongxing
๐ค Zhou, Gangqiao
๐ค Zhi, Lianteng
๐ค Yang, Hao
๐ค Zhai, Yun
๐ค Dong, Xiaojia
๐ค Zhang, Xiumei
๐ค Gao, Xue
๐ค Zhu, Yunping
๐ค He, Fuchu
year
โฐ 2005
issn
๐ 00221899
volume
192
number
8
page
1355-1361
citedbycount
63
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