📄 Severe acute respiratory syndrome coronavirus protein 6 is required for optimal replication

Severe acute respiratory syndrome coronavirus (SARS-CoV) encodes several accessory proteins of unknown function. One of these proteins, protein 6 (p6), which is encoded by ORF6, enhances virus replication when introduced into a heterologous murine coronavirus (mouse hepatitis virus [MHV]) but is not essential for optimal SARS-CoV replication after infection at a relatively high multiplicity of infection (MOI). Here, we reconcile these apparently conflicting results by showing that p6 enhances SARS-CoV replication to nearly the same extent as when expressed in the context of MHV if cells are infected at a low MOI and accelerates disease in mice transgenic for the human SARS-CoV receptor. Copyright © 2009, American Society for Microbiology.

keywords 🔗 syndrome coronavirus (1074) 🔗 hepatitis virus (437) 🔗 mouse hepatitis (371) 🔗 virus replication (219) 🔗 murine coronavirus (140) 🔗 respiratory syndrome (2004) 🔗 acute respiratory (1734) 🔗 accessory proteins (53)

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