📄 Molecular biology of severe acute respiratory syndrome coronavirus

The worldwide epidemic of severe acute respiratory syndrome (SARS) in 2003 was caused by a novel coronavirus called SARS-CoV. Coronaviruses and their closest relatives possess extremely large plus-strand RNA genomes and employ unique mechanisms and enzymes in RNA synthesis that separate them from all other RNA viruses. The SARS epidemic prompted a variety of studies on multiple aspects of the coronavirus replication cycle, yielding both rapid identification of the entry mechanisms of SARS-CoV into host cells and valuable structural and functional information on SARS-CoV proteins. These recent advances in coronavirus research have important implications for the development of anti-SARS drugs and vaccines. © 2004 Elsevier Ltd.

keywords 🔗 severe acute (1373) 🔗 host cell (262) 🔗 novel coronavirus (684) 🔗 virus replication (219) 🔗 respiratory syndrome (2004) 🔗 acute respiratory (1734)

download 🔖 [BibTeX]