๐ Development of epitope-based peptide vaccine against novel coronavirus 2019 (SARS-COV-2): Immunoinformatics approach.
Recently, a novel coronavirus (SARS-COV-2) emerged which is responsible for the recent outbreak in Wuhan, China. Genetically, it is closely related to SARS-CoV and MERS-CoV. The situation is getting worse and worse, therefore, there is an urgent need for designing a suitable peptide vaccine component against the SARS-COV-2. Here, we characterized spike glycoprotein to obtain immunogenic epitopes. Next, we chose 13 Major Histocompatibility Complex-(MHC) I and 3 MHC-II epitopes, having antigenic properties. These epitopes are usually linked to specific linkers to build vaccine components and molecularly dock on toll-like receptor-5 to get binding affinity. Therefore, to provide a fast immunogenic profile of these epitopes, we performed immunoinformatics analysis so that the rapid development of the vaccine might bring this disastrous situation to the end earlier.
keywords
๐ SARS-COV-2 (551)
๐ epitopes (136)
๐ immunoinformatics (2)
๐ vaccine (599)
๐ closely related (222)
๐ novel coronavirus (684)
๐ spike glycoprotein (99)
author
๐ค Bhattacharya, Manojit
๐ค Sharma, Ashish R
๐ค Patra, Prasanta
๐ค Ghosh, Pratik
๐ค Sharma, Garima
๐ค Patra, Bidhan C
๐ค Lee, Sang-Soo
๐ค Chakraborty, Chiranjib
year
โฐ 2020
journal
๐ J Med Virol
issn
๐
volume
number
page
citedbycount
0
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