๐ An experimental model for myocarditis and congestive heart failure after rabbit coronavirus infection
In a model for virus-induced myocarditis and congestive heart failure, rabbit coronavirus infection was divided into acute (days 2-5) and subacute (days 6-12) phases on the basis of day of death and pathologic findings. During the acute phase, the principal histologic lesions were degeneration and necrosis of myocytes, myocytolysis, interstitial edema, and hemorrhage. The severity of these changes increased in the subacute phase. Pleural effusion and congestion of the lungs and liver were also present at this time. Myocarditis was detected by day 9 and peaked by day 12. Heart weights and heart weight-to-body weight ratios were increased, and dilation of the right ventricular cavity became prominent early in infection and persisted. In contrast, dilation of the left ventricle occurred late in the subacute stage. Virus was isolated from infected hearts between days 2 and 12. These data suggest that rabbit coronavirus infection progresses to myocarditis and congestive heart failure. ยฉ 1992 Oxford University Press.
author
๐ค Edwards, Suzanne
๐ค David Small, J.
๐ค Geratz, Joachim Dieter
๐ค Alexander, Lorraine K.
๐ค Baric, Ralph S.
year
โฐ 1992
issn
๐ 15376613 00221899
volume
165
number
1
page
134-140
citedbycount
11
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