📄 Sequence analysis of the nucleocapsid protein gene of rat coronavirus SDAV-681

The nucleotide sequence of the 3’-end of the genomic RNA of sialodacryoadenitis virus strain 681 (SDAV-681) was determined. A large open reading frame encoding a 454-amino-acid protein was identified as the nucleocapsid protein (N) gene, since the predicted protein is similar in size, chemical properties, and amino acid sequence to the N proteins of other coronaviruses. The amino acid variance of the N proteins between SDAV and mouse hepatitis virus (MHV) is not markedly different from that among MHV strains. A high degree of genetic relatedness between SDAV and MHV was revealed in the intergenic and 3’-noncoding sequences as well as in the N gene. © 1993 Academic Press.

keywords 🔗 reading frame (222) 🔗 nucleotide sequence (93) 🔗 hepatitis virus (437) 🔗 acid sequence (108) 🔗 amino acid (454) 🔗 mouse hepatitis (371) 🔗 nucleocapsid protein (162) 🔗 virus strain (138) 🔗 open reading (215)

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