📄 The ADP-ribose-1″-monophosphatase domains of severe acute respiratory syndrome coronavirus and human coronavirus 229E mediate resistance to antiviral interferon responses

Several plus-strand RNA viruses encode proteins containing macrodomains. These domains possess ADP-ribose-1″-phosphatase (ADRP) activity and/or bind poly(ADP-ribose), poly(A) or poly(G). The relevance of these activities in the viral life cycle has not yet been resolved. Here, we report that genetically engineered mutants of severe acute respiratory syndrome coronavirus (SARS-CoV) and human coronavirus 229E (HCoV-229E) expressing ADRP-deficient macrodomains displayed an increased sensitivity to the antiviral effect of alpha interferon compared with their wild-type counterparts. The data suggest that macrodomain-associated ADRP activities may have a role in viral escape from the innate immune responses of the host. © 2011.

keywords 🔗 severe acute (1373) 🔗 syndrome coronavirus (1074) 🔗 life cycle (63) 🔗 innate immune (105) 🔗 human coronavirus (623) 🔗 immune response (314) 🔗 data suggest (146) 🔗 immune responses (142) 🔗 respiratory syndrome (2004) 🔗 acute respiratory (1734)

download 🔖 [BibTeX]