📄 Human CD4+ memory T-lymphocyte responses to SARS coronavirus infection

Little is known about CD4+ T-cell immunity to the severe acute respiratory syndrome (SARS) coronavirus. In two SARS patients, we examined the memory CD4+ T-cell responses to peptides derived from SARS coronavirus structural proteins. We generated CD4+ T-cell lines to 3 peptides from the spike (S) protein and defined their HLA restriction. In one patient, the predominant memory CD4+ T-cell response was directed against an epitope outside the S protein receptor-binding domain. In both patients, the frequency of CD4+ memory T-cells to virus structural proteins and anti-SARS coronavirus IgG levels were low by 12 months after infection. This report expands our understanding of the specificity and duration of anti-SARS coronavirus CD4+ T-cell immune responses. © 2007 Elsevier Inc.

keywords 🔗 severe acute (1373) 🔗 receptor-binding domain (99) 🔗 cell lines (125) 🔗 immune response (314) 🔗 structural proteins (197) 🔗 immune responses (142) 🔗 respiratory syndrome (2004) 🔗 acute respiratory (1734) 🔗 cell line (211)

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