📄 Enhanced isolation of SARS-CoV-2 by TMPRSS2-expressing cells.

A novel betacoronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which caused a large respiratory outbreak in Wuhan, China in December 2019, is currently spreading across many countries globally. Here, we show that a TMPRSS2-expressing VeroE6 cell line is highly susceptible to SARS-CoV-2 infection, making it useful for isolating and propagating SARS-CoV-2. Our results reveal that, in common with SARS- and Middle East respiratory syndrome-CoV, SARS-CoV-2 infection is enhanced by TMPRSS2.

keywords 🔗 *SARS-CoV-2 (551) 🔗 *TMPRSS2 (26) 🔗 *VeroE6 () 🔗 *coronavirus (5664) 🔗 *outbreak (1126) 🔗 severe acute (1373) 🔗 syndrome coronavirus (1074) 🔗 respiratory syndrome (2004) 🔗 acute respiratory (1734) 🔗 cell line (211)

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