🔗 Tmprss2

Articles (26)

• TMPRSS2 activates the human coronavirus 229E for cathepsin-independent host cell entry and is expressed in viral target cells in the respiratory epithelium

  👤 Bertram, Stephanie 👤 Dijkman, Ronald 👤 Habjan, Matthias 👤 Heurich, Adeline 👤 Gierer, Stefanie 👤 Glowacka, Ilona 👤 Welsch, Kathrin 👤 Winkler, Michael 👤 Schneider, Heike 👤 Hofmann-Winkler, Heike 👤 Volker Thiel, None 👤 Pöhlmann, Stefan ⏰ 2013 📚 Journal of Virology

• Cleavage and activation of the severe acute respiratory syndrome coronavirus spike protein by human airway trypsin-like protease

  👤 Bertram, Stephanie 👤 Glowacka, Ilona 👤 Müller, Marcel A. 👤 Lavender, Hayley 👤 Gnirss, Kerstin 👤 Nehlmeier, Inga 👤 Niemeyer, Daniela 👤 He, Yuxian 👤 Simmons, Graham 👤 Drosten, Christian 👤 Soilleux, Elizabeth J. 👤 Jahn, Olaf 👤 Steffen, Imke 👤 Pöhlmann, Stefan ⏰ 2011 📚 Journal of Virology

• Influenza and SARS-coronavirus activating proteases TMPRSS2 and HAT are expressed at multiple sites in human respiratory and gastrointestinal tracts

  👤 Bertram, Stephanie 👤 Heurich, Adeline 👤 Lavender, Hayley 👤 Gierer, Stefanie 👤 Danisch, Simon 👤 Perin, Paula 👤 Lucas, Jared M. 👤 Nelson, Peter S. 👤 Pöhlmann, Stefan 👤 Soilleux, Elizabeth J. ⏰ 2012 📚 PLoS ONE

• The tetraspanin CD9 facilitates MERS-coronavirus entry by scaffolding host cell receptors and proteases

  👤 Earnest, James T. 👤 Hantak, Michael P. 👤 Li, Kun 👤 McCray, Paul B. 👤 Perlman, Stanley 👤 Gallagher, Tom ⏰ 2017 📚 PLoS Pathogens

• The spike protein of the emerging betacoronavirus EMC uses a novel coronavirus receptor for entry, can be activated by TMPRSS2, and is targeted by neutralizing antibodies

  👤 Gierer, Stefanie 👤 Bertram, Stephanie 👤 Kaup, Franziska 👤 Wrensch, Florian 👤 Heurich, Adeline 👤 Krämer-Kühl, Annika 👤 Welsch, Kathrin 👤 Winkler, Michael 👤 Meyer, Benjamin 👤 Drosten, Christian 👤 Dittmer, Ulf 👤 von Hahn, Thomas 👤 Simmons, Graham 👤 Hofmann, Heike 👤 Pöhlmann, Stefan ⏰ 2013 📚 Journal of Virology

• Evidence that TMPRSS2 activates the severe acute respiratory syndrome coronavirus spike protein for membrane fusion and reduces viral control by the humoral immune response

  👤 Glowacka, Ilona 👤 Bertram, Stephanie 👤 Müller, Marcel A. 👤 Allen, Paul 👤 Soilleux, Elizabeth 👤 Pfefferle, Susanne 👤 Steffen, Imke 👤 Tsegaye, Theodros Solomon 👤 He, Yuxian 👤 Gnirss, Kerstin 👤 Niemeyer, Daniela 👤 Schneider, Heike 👤 Drosten, Christian 👤 Pöhlmann, Stefan ⏰ 2011 📚 Journal of Virology

• TMPRSS2 and ADAM17 cleave ACE2 differentially and only proteolysis by TMPRSS2 augments entry driven by the severe acute respiratory syndrome coronavirus spike protein

  👤 Heurich, Adeline 👤 Hofmann-Winkler, Heike 👤 Gierer, Stefanie 👤 Liepold, Thomas 👤 Jahn, Olaf 👤 Pöhlmann, Stefan ⏰ 2014 📚 Journal of Virology

• SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor.

  👤 Hoffmann, Markus 👤 Kleine-Weber, Hannah 👤 Schroeder, Simon 👤 Kruger, Nadine 👤 Herrler, Tanja 👤 Erichsen, Sandra 👤 Schiergens, Tobias S 👤 Herrler, Georg 👤 Wu, Nai-Huei 👤 Nitsche, Andreas 👤 Muller, Marcel A 👤 Drosten, Christian 👤 Pohlmann, Stefan ⏰ 2020 📚 Cell

• TMPRSS2 contributes to virus spread and immunopathology in the airways of murine models after coronavirus infection

  👤 Iwata-Yoshikawa, Naoko 👤 Okamura, Tadashi 👤 Shimizu, Yukiko 👤 Hasegawa, Hideki 👤 Takeda, Makoto 👤 Nagata, Noriyo ⏰ 2019 📚 Journal of Virology

• Simultaneous treatment of human bronchial epithelial cells with serine and cysteine protease inhibitors prevents severe acute respiratory syndrome coronavirus entry

  👤 Kawase, Miyuki 👤 Shirato, Kazuya 👤 van der Hoek, Lia 👤 Taguchi, Fumihiro 👤 Matsuyama, Shutoku ⏰ 2012 📚 Journal of Virology

• Functional analysis of potential cleavage sites in the MERS-coronavirus spike protein

  👤 Kleine-Weber, Hannah 👤 Elzayat, Mahmoud Tarek 👤 Hoffmann, Markus 👤 Pöhlmann, Stefan ⏰ 2018 📚 Scientific Reports

• Transplantation of ACE2(-) Mesenchymal Stem Cells Improves the Outcome of Patients with COVID-19 Pneumonia.

  👤 Leng, Zikuan 👤 Zhu, Rongjia 👤 Hou, Wei 👤 Feng, Yingmei 👤 Yang, Yanlei 👤 Han, Qin 👤 Shan, Guangliang 👤 Meng, Fanyan 👤 Du, Dongshu 👤 Wang, Shihua 👤 Fan, Junfen 👤 Wang, Wenjing 👤 Deng, Luchan 👤 Shi, Hongbo 👤 Li, Hongjun 👤 Hu, Zhongjie 👤 Zhang, Fengchun 👤 Gao, Jinming 👤 Liu, Hongjian 👤 Li, Xiaoxia 👤 Zhao, Yangyang 👤 Yin, Kan 👤 He, Xijing 👤 Gao, Zhengchao 👤 Wang, Yibin 👤 Yang, Bo 👤 Jin, Ronghua 👤 Stambler, Ilia 👤 Lim, Lee Wei 👤 Su, Huanxing 👤 Moskalev, Alexey 👤 Cano, Antonio 👤 Chakrabarti, Sasanka 👤 Min, Kyung-Jin 👤 Ellison-Hughes, Georgina 👤 Caruso, Calogero 👤 Jin, Kunlin 👤 Zhao, Robert Chunhua ⏰ 2020 📚 Aging Dis

• SARS-CoV-2 receptor ACE2 and TMPRSS2 are primarily expressed in bronchial transient secretory cells.

  👤 Lukassen, Soeren 👤 Lorenz Chua, Robert 👤 Trefzer, Timo 👤 Kahn, Nicolas C 👤 Schneider, Marc A 👤 Muley, Thomas 👤 Winter, Hauke 👤 Meister, Michael 👤 Veith, Carmen 👤 Boots, Agnes W 👤 Hennig, Bianca P 👤 Kreuter, Michael 👤 Conrad, Christian 👤 Eils, Roland ⏰ 2020 📚 EMBO J

• Efficient activation of the severe acute respiratory syndrome coronavirus spike protein by the transmembrane protease TMPRSS2

  👤 Matsuyama, Shutoku 👤 Nagata, Noriyo 👤 Shirato, Kazuya 👤 Kawase, Miyuki 👤 Takeda, Makoto 👤 Taguchi, Fumihiro ⏰ 2010 📚 Journal of Virology

• Enhanced isolation of SARS-CoV-2 by TMPRSS2-expressing cells.

  👤 Matsuyama, Shutoku 👤 Nao, Naganori 👤 Shirato, Kazuya 👤 Kawase, Miyuki 👤 Saito, Shinji 👤 Takayama, Ikuyo 👤 Nagata, Noriyo 👤 Sekizuka, Tsuyoshi 👤 Katoh, Hiroshi 👤 Kato, Fumihiro 👤 Sakata, Masafumi 👤 Tahara, Maino 👤 Kutsuna, Satoshi 👤 Ohmagari, Norio 👤 Kuroda, Makoto 👤 Suzuki, Tadaki 👤 Kageyama, Tsutomu 👤 Takeda, Makoto ⏰ 2020 📚 Proc Natl Acad Sci U S A

• Middle east respiratory syndrome coronavirus spike protein is not activated directly by cellular furin during viral entry into target cells

  👤 Matsuyama, Shutoku 👤 Shirato, Kazuya 👤 Kawase, Miyuki 👤 Terada, Yutaka 👤 Kawachi, Kengo 👤 Fukushi, Shuetsu 👤 Kamitani, Wataru ⏰ 2018 📚 Journal of Virology

• Neurovirulent murine coronavirus JHM.SD uses cellular zinc metalloproteases for virus entry and cell-cell fusion

  👤 Phillips, Judith M. 👤 Gallagher, Tom 👤 Weiss, Susan R. ⏰ 2017 📚 Journal of Virology

• TMPRSS2: A potential target for treatment of influenza virus and coronavirus infections

  👤 Shen, Li Wen 👤 Mao, Hui Juan 👤 Wu, Yan Ling 👤 Tanaka, Yoshimasa 👤 Zhang, Wen ⏰ 2017 📚 Biochimie

• Clinical isolates of human coronavirus 229E bypass the endosome for cell entry

  👤 Shirato, Kazuya 👤 Kanou, Kazuhiko 👤 Kawase, Miyuki 👤 Matsuyama, Shutoku ⏰ 2017 📚 Journal of Virology

• Middle east respiratory syndrome coronavirus infection mediated by the transmembrane serine protease TMPRSS2

  👤 Shirato, Kazuya 👤 Kawase, Miyuki 👤 Matsuyama, Shutoku ⏰ 2013 📚 Journal of Virology

• Wild-type human coronaviruses prefer cell-surface TMPRSS2 to endosomal cathepsins for cell entry

  👤 Shirato, Kazuya 👤 Kawase, Miyuki 👤 Matsuyama, Shutoku ⏰ 2018 📚 Virology

• A transmembrane serine protease is linked to the severe acute respiratory syndrome coronavirus receptor and activates virus entry

  👤 Shulla, Ana 👤 Heald-Sargent, Taylor 👤 Subramanya, Gitanjali 👤 Zhao, Jincun 👤 Perlman, Stanley 👤 Gallagher, Tom ⏰ 2011 📚 Journal of Virology

• Comparative analysis of the activation of unfolded protein response by spike proteins of severe acute respiratory syndrome coronavirus and human coronavirus HKU1

  👤 Siu, Kam Leung 👤 Chan, Ching Ping 👤 Kok, Kin Hang 👤 Woo, Patrick C.Y. 👤 Jin, Dong Yan ⏰ 2014 📚 Cell and Bioscience

• Protease inhibitors targeting coronavirus and filovirus entry

  👤 Zhou, Yanchen 👤 Vedantham, Punitha 👤 Lu, Kai 👤 Agudelo, Juliet 👤 Carrion, Ricardo 👤 Nunneley, Jerritt W. 👤 Barnard, Dale 👤 Pöhlmann, Stefan 👤 McKerrow, James H. 👤 Renslo, Adam R. 👤 Simmons, Graham ⏰ 2015 📚 Antiviral Research

• DESC1 and MSPL activate influenza a viruses and emerging coronaviruses for host cell entry

  👤 Zmora, Pawel 👤 Blazejewska, Paulina 👤 Moldenhauer, Anna Sophie 👤 Welsch, Kathrin 👤 Nehlmeier, Inga 👤 Wu, Qingyu 👤 Schneider, Heike 👤 Pöhlmann, Stefan 👤 Bertram, Stephanie ⏰ 2014 📚 Journal of Virology

• TMPRSS11A activates the influenza A virus hemagglutinin and the MERS coronavirus spike protein and is insensitive against blockade by HAI-1

  👤 Zmora, Pawel 👤 Hoffmann, Markus 👤 Kollmus, Heike 👤 Moldenhauer, Anna Sophie 👤 Danov, Olga 👤 Braun, Armin 👤 Winkler, Michael 👤 Schughart, Klaus 👤 Stefan Pöhlmann, X. ⏰ 2018 📚 Journal of Biological Chemistry