👤 Pöhlmann, Stefan
Keywords
Articles (26)
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TMPRSS2 activates the human coronavirus 229E for cathepsin-independent host cell entry and is expressed in viral target cells in the respiratory epithelium
👤 Bertram, Stephanie 👤 Dijkman, Ronald 👤 Habjan, Matthias 👤 Heurich, Adeline 👤 Gierer, Stefanie 👤 Glowacka, Ilona 👤 Welsch, Kathrin 👤 Winkler, Michael 👤 Schneider, Heike 👤 Hofmann-Winkler, Heike 👤 Volker Thiel, None 👤 Pöhlmann, Stefan ⏰ 2013 📚 Journal of Virology
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Cleavage and activation of the severe acute respiratory syndrome coronavirus spike protein by human airway trypsin-like protease
👤 Bertram, Stephanie 👤 Glowacka, Ilona 👤 Müller, Marcel A. 👤 Lavender, Hayley 👤 Gnirss, Kerstin 👤 Nehlmeier, Inga 👤 Niemeyer, Daniela 👤 He, Yuxian 👤 Simmons, Graham 👤 Drosten, Christian 👤 Soilleux, Elizabeth J. 👤 Jahn, Olaf 👤 Steffen, Imke 👤 Pöhlmann, Stefan ⏰ 2011 📚 Journal of Virology
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Influenza and SARS-coronavirus activating proteases TMPRSS2 and HAT are expressed at multiple sites in human respiratory and gastrointestinal tracts
👤 Bertram, Stephanie 👤 Heurich, Adeline 👤 Lavender, Hayley 👤 Gierer, Stefanie 👤 Danisch, Simon 👤 Perin, Paula 👤 Lucas, Jared M. 👤 Nelson, Peter S. 👤 Pöhlmann, Stefan 👤 Soilleux, Elizabeth J. ⏰ 2012 📚 PLoS ONE
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The spike protein of the emerging betacoronavirus EMC uses a novel coronavirus receptor for entry, can be activated by TMPRSS2, and is targeted by neutralizing antibodies
👤 Gierer, Stefanie 👤 Bertram, Stephanie 👤 Kaup, Franziska 👤 Wrensch, Florian 👤 Heurich, Adeline 👤 Krämer-Kühl, Annika 👤 Welsch, Kathrin 👤 Winkler, Michael 👤 Meyer, Benjamin 👤 Drosten, Christian 👤 Dittmer, Ulf 👤 von Hahn, Thomas 👤 Simmons, Graham 👤 Hofmann, Heike 👤 Pöhlmann, Stefan ⏰ 2013 📚 Journal of Virology
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Lack of MERS coronavirus neutralizing antibodies in humans, Eastern Province, Saudi Arabia
👤 Gierer, Stefanie 👤 Hofmann-Winkler, Heike 👤 Albuali, Waleed H. 👤 Bertram, Stephanie 👤 Al-Rubaish, Abdullah M. 👤 Yousef, Abdullah A. 👤 Al-Nafaie, Awatif N. 👤 Al-Ali, Amein K. 👤 Obeid, Obeid E. 👤 Alkharsah, Khaled R. 👤 Pöhlmann, Stefan ⏰ 2013 📚 Emerging Infectious Diseases
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Inhibition of proprotein convertases abrogates processing of the middle eastern respiratory syndrome coronavirus spike protein in infected cells but does not reduce viral infectivity
👤 Gierer, Stefanie 👤 Müller, Marcel A. 👤 Heurich, Adeline 👤 Ritz, Daniel 👤 Springstein, Benjamin L. 👤 Karsten, Christina B. 👤 Schendzielorz, Alexander 👤 Gnirß, Kerstin 👤 Drosten, Christian 👤 Pöhlmann, Stefan ⏰ 2015 📚 Journal of Infectious Diseases
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Differential downregulation of ACE2 by the spike proteins of severe acute respiratory syndrome coronavirus and human coronavirus NL63
👤 Glowacka, Ilona 👤 Bertram, Stephanie 👤 Herzog, Petra 👤 Pfefferle, Susanne 👤 Steffen, Imke 👤 Muench, Marcus O. 👤 Simmons, Graham 👤 Hofmann, Heike 👤 Kuri, Thomas 👤 Weber, Friedemann 👤 Eichler, Jutta 👤 Drosten, Christian 👤 Pöhlmann, Stefan ⏰ 2010 📚 Journal of Virology
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Evidence that TMPRSS2 activates the severe acute respiratory syndrome coronavirus spike protein for membrane fusion and reduces viral control by the humoral immune response
👤 Glowacka, Ilona 👤 Bertram, Stephanie 👤 Müller, Marcel A. 👤 Allen, Paul 👤 Soilleux, Elizabeth 👤 Pfefferle, Susanne 👤 Steffen, Imke 👤 Tsegaye, Theodros Solomon 👤 He, Yuxian 👤 Gnirss, Kerstin 👤 Niemeyer, Daniela 👤 Schneider, Heike 👤 Drosten, Christian 👤 Pöhlmann, Stefan ⏰ 2011 📚 Journal of Virology
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LSECtin interacts with filovirus glycoproteins and the spike protein of SARS coronavirus
👤 Gramberg, Thomas 👤 Hofmann, Heike 👤 Möller, Peggy 👤 Lalor, Patricia F. 👤 Marzi, Andrea 👤 Geier, Martina 👤 Krumbiegel, Mandy 👤 Winkler, Thomas 👤 Kirchhoff, Frank 👤 Adams, David H. 👤 Becker, Stephan 👤 Münch, Jan 👤 Pöhlmann, Stefan ⏰ 2005 📚 Virology
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TMPRSS2 and ADAM17 cleave ACE2 differentially and only proteolysis by TMPRSS2 augments entry driven by the severe acute respiratory syndrome coronavirus spike protein
👤 Heurich, Adeline 👤 Hofmann-Winkler, Heike 👤 Gierer, Stefanie 👤 Liepold, Thomas 👤 Jahn, Olaf 👤 Pöhlmann, Stefan ⏰ 2014 📚 Journal of Virology
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SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor.
👤 Hoffmann, Markus 👤 Kleine-Weber, Hannah 👤 Schroeder, Simon 👤 Kruger, Nadine 👤 Herrler, Tanja 👤 Erichsen, Sandra 👤 Schiergens, Tobias S 👤 Herrler, Georg 👤 Wu, Nai-Huei 👤 Nitsche, Andreas 👤 Muller, Marcel A 👤 Drosten, Christian 👤 Pohlmann, Stefan ⏰ 2020 📚 Cell
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Susceptibility to SARS coronavirus S protein-driven infection correlates with expression of angiotensin converting enzyme 2 and infection can be blocked by soluble receptor
👤 Hofmann, Heike 👤 Geier, Martina 👤 Marzi, Andrea 👤 Krumbiegel, Mandy 👤 Peipp, Matthias 👤 Fey, Georg H. 👤 Gramberg, Thomas 👤 Pöhlmann, Stefan ⏰ 2004 📚 Biochemical and Biophysical Research Communications
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S protein of severe acute respiratory syndrome-associated coronavirus mediates entry into hepatoma cell lines and is targeted by neutralizing antibodies in infected patients
👤 Hofmann, Heike 👤 Hattermann, Kim 👤 Marzi, Andrea 👤 Gramberg, Thomas 👤 Geier, Martina 👤 Krumbiegel, Mandy 👤 Kuate, Seraphin 👤 Überla, Klaus 👤 Niedrig, Matthias 👤 Pöhlmann, Stefan ⏰ 2004 📚 Journal of Virology
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Human coronavirus NL63 employs the severe acute respiratory syndrome coronavirus receptor for cellular entry
👤 Hofmann, Heike 👤 Pyrc, Krzysztof 👤 Van Der Hoek, Lia 👤 Geier, Martina 👤 Berkhout, Ben 👤 Pöhlmann, Stefan ⏰ 2005 📚 Proceedings of the National Academy of Sciences of the United States of America
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Cellular entry of the SARS coronavirus
👤 Hofmann, Heike 👤 Pöhlmann, Stefan ⏰ 2004 📚 Trends in Microbiology
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Highly conserved regions within the spike proteins of human coronaviruses 229E and NL63 determine recognition of their respective cellular receptors
👤 Hofmann, Heike 👤 Simmons, Graham 👤 Rennekamp, Andrew J. 👤 Chaipan, Chawaree 👤 Gramberg, Thomas 👤 Heck, Elke 👤 Geier, Martina 👤 Wegele, Anja 👤 Marzi, Andrea 👤 Bates, Paul 👤 Pöhlmann, Stefan ⏰ 2006 📚 Journal of Virology
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Functional analysis of potential cleavage sites in the MERS-coronavirus spike protein
👤 Kleine-Weber, Hannah 👤 Elzayat, Mahmoud Tarek 👤 Hoffmann, Markus 👤 Pöhlmann, Stefan ⏰ 2018 📚 Scientific Reports
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Spike proteins of novel MERS-coronavirus isolates from North- and West-African dromedary camels mediate robust viral entry into human target cells
👤 Kleine-Weber, Hannah 👤 Pöhlmann, Stefan 👤 Hoffmann, Markus ⏰ 2019 📚 Virology
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DC-SIGN and DC-SIGNR interact with the glycoprotein of marburg virus and the S protein of severe acute respiratory syndrome coronavirus
👤 Marzi, Andrea 👤 Gramberg, Thomas 👤 Simmons, Graham 👤 Möller, Peggy 👤 Rennekamp, Andrew J. 👤 Krumbiegel, Mandy 👤 Geier, Martina 👤 Eisemann, Jutta 👤 Turza, Nadine 👤 Saunier, Bertrand 👤 Steinkasserer, Alexander 👤 Becker, Stephan 👤 Bates, Paul 👤 Hofmann, Heike 👤 Pöhlmann, Stefan ⏰ 2004 📚 Journal of Virology
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The SARS-Coronavirus-host interactome: Identification of cyclophilins as target for pan-Coronavirus inhibitors
👤 Pfefferle, Susanne 👤 Schöpf, Julia 👤 Kögl, Manfred 👤 Friedel, Caroline C. 👤 Müller, Marcel A. 👤 Carbajo-Lozoya, Javier 👤 Stellberger, Thorsten 👤 von Dall'Armi, Ekatarina 👤 Herzog, Petra 👤 Kallies, Stefan 👤 Niemeyer, Daniela 👤 Ditt, Vanessa 👤 Kuri, Thomas 👤 Züst, Roland 👤 Pumpor, Ksenia 👤 Hilgenfeld, Rolf 👤 Schwarz, Frank 👤 Zimmer, Ralf 👤 Steffen, Imke 👤 Weber, Friedemann 👤 Thiel, Volker 👤 Herrler, Georg 👤 Thiel, Heinz Jürgen 👤 Schwegmann-Weßels, Christel 👤 Pöhlmann, Stefan 👤 Haas, Jürgen 👤 Drosten, Christian 👤 von Brunn, Albrecht ⏰ 2011 📚 PLoS Pathogens
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Different host cell proteases activate the SARS-coronavirus spike-protein for cell-cell and virus-cell fusion
👤 Simmons, Graham 👤 Bertram, Stephanie 👤 Glowacka, Ilona 👤 Steffen, Imke 👤 Chaipan, Chawaree 👤 Agudelo, Juliet 👤 Lu, Kai 👤 Rennekamp, Andrew J. 👤 Hofmann, Heike 👤 Bates, Paul 👤 Pöhlmann, Stefan ⏰ 2011 📚 Virology
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Proteolytic activation of the SARS-coronavirus spike protein: Cutting enzymes at the cutting edge of antiviral research
👤 Simmons, Graham 👤 Zmora, Pawel 👤 Gierer, Stefanie 👤 Heurich, Adeline 👤 Pöhlmann, Stefan ⏰ 2013 📚 Antiviral Research
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IFITM proteins inhibit entry driven by the MERS-Coronavirus Spike protein: Evidence for Cholesterol-Independent Mechanisms
👤 Wrensch, Florian 👤 Winkler, Michael 👤 Pöhlmann, Stefan ⏰ 2014 📚 Viruses
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A single asparagine-linked glycosylation site of the severe acute respiratory syndrome coronavirus spike glycoprotein facilitates inhibition by mannose-binding lectin through multiple mechanisms
👤 Zhou, Yanchen 👤 Lu, Kai 👤 Pfefferle, Susanne 👤 Bertram, Stephanie 👤 Glowacka, Ilona 👤 Drosten, Christian 👤 Pöhlmann, Stefan 👤 Simmons, Graham ⏰ 2010 📚 Journal of Virology
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Protease inhibitors targeting coronavirus and filovirus entry
👤 Zhou, Yanchen 👤 Vedantham, Punitha 👤 Lu, Kai 👤 Agudelo, Juliet 👤 Carrion, Ricardo 👤 Nunneley, Jerritt W. 👤 Barnard, Dale 👤 Pöhlmann, Stefan 👤 McKerrow, James H. 👤 Renslo, Adam R. 👤 Simmons, Graham ⏰ 2015 📚 Antiviral Research
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DESC1 and MSPL activate influenza a viruses and emerging coronaviruses for host cell entry
👤 Zmora, Pawel 👤 Blazejewska, Paulina 👤 Moldenhauer, Anna Sophie 👤 Welsch, Kathrin 👤 Nehlmeier, Inga 👤 Wu, Qingyu 👤 Schneider, Heike 👤 Pöhlmann, Stefan 👤 Bertram, Stephanie ⏰ 2014 📚 Journal of Virology