🔗 Cell-cell fusion

Articles (34)

• Activation of the SARS coronavirus spike protein via sequential proteolytic cleavage at two distinct sites

  👤 Belouzard, Sandrine 👤 Chu, Victor C. 👤 Whittaker, Gary R. ⏰ 2009 📚 Proceedings of the National Academy of Sciences of the United States of America

• TMPRSS2 activates the human coronavirus 229E for cathepsin-independent host cell entry and is expressed in viral target cells in the respiratory epithelium

  👤 Bertram, Stephanie 👤 Dijkman, Ronald 👤 Habjan, Matthias 👤 Heurich, Adeline 👤 Gierer, Stefanie 👤 Glowacka, Ilona 👤 Welsch, Kathrin 👤 Winkler, Michael 👤 Schneider, Heike 👤 Hofmann-Winkler, Heike 👤 Volker Thiel, None 👤 Pöhlmann, Stefan ⏰ 2013 📚 Journal of Virology

• Cleavage and activation of the severe acute respiratory syndrome coronavirus spike protein by human airway trypsin-like protease

  👤 Bertram, Stephanie 👤 Glowacka, Ilona 👤 Müller, Marcel A. 👤 Lavender, Hayley 👤 Gnirss, Kerstin 👤 Nehlmeier, Inga 👤 Niemeyer, Daniela 👤 He, Yuxian 👤 Simmons, Graham 👤 Drosten, Christian 👤 Soilleux, Elizabeth J. 👤 Jahn, Olaf 👤 Steffen, Imke 👤 Pöhlmann, Stefan ⏰ 2011 📚 Journal of Virology

• The coronavirus spike protein is a class I virus fusion protein: Structural and functional characterization of the fusion core complex

  👤 Bosch, Berend Jan 👤 Van der Zee, Ruurd 👤 De Haan, Cornelis A.M. 👤 Rottier, Peter J.M. ⏰ 2003 📚 Journal of Virology

• Important role for the transmembrane domain of severe acute respiratory syndrome coronavirus spike protein during entry

  👤 Broer, Rene 👤 Boson, Bertrand 👤 Spaan, Willy 👤 Cosset, François Loïc 👤 Corver, Jeroen ⏰ 2006 📚 Journal of Virology

• Protective effect of intranasal regimens containing peptidic middle east respiratory syndrome coronavirus fusion inhibitor against MERS-CoV infection

  👤 Channappanavar, Rudragouda 👤 Lu, Lu 👤 Xia, Shuai 👤 Du, Lanying 👤 Meyerholz, David K. 👤 Perlman, Stanley 👤 Jiang, Shibo ⏰ 2015 📚 Journal of Infectious Diseases

• Murine coronavirus requires lipid rafts for virus entry and cell-cell fusion but not for virus release

  👤 Choi, Keum S. 👤 Aizaki, Hideki 👤 Lai, Michael M.C. ⏰ 2005 📚 Journal of Virology

• The use of hepatitis C virus NS3/4A and secreted alkaline phosphatase to quantitate cell-cell membrane fusion mediated by severe acute respiratory syndrome coronavirus S protein and the receptor angiotensin-converting enzyme 2

  👤 Chou, Chih Fong 👤 Shen, Shuo 👤 Mahadevappa, Geetha 👤 Lim, Seng Gee 👤 Hong, Wanjin 👤 Tan, Yee Joo ⏰ 2007 📚 Analytical Biochemistry

• Mutagenesis of the transmembrane domain of the SARS coronavirus spike glycoprotein: Refinement of the requirements for SARS coronavirus cell entry

  👤 Corver, Jeroen 👤 Broer, Rene 👤 Van Kasteren, Puck 👤 Spaan, Willy ⏰ 2009 📚 Virology Journal

• Cleavage inhibition of the murine coronavirus spike protein by a furin-like enzyme affects cell-cell but not virus-cell fusion

  👤 De Haan, Cornelis A.M. 👤 Stadler, Konrad 👤 Godeke, Gert Jan 👤 Bosch, Berend Jan 👤 Rottier, Peter J.M. ⏰ 2004 📚 Journal of Virology

• Serine-scanning mutagenesis studies of the C-terminal heptad repeats in the SARS coronavirus S glycoprotein highlight the important role of the short helical region

  👤 Follis, Kathryn E. 👤 York, Joanne 👤 Nunberg, Jack H. ⏰ 2005 📚 Virology

• Furin cleavage of the SARS coronavirus spike glycoprotein enhances cell-cell fusion but does not affect virion entry

  👤 Follis, Kathryn E. 👤 York, Joanne 👤 Nunberg, Jack H. ⏰ 2006 📚 Virology

• Aromatic amino acids in the juxtamembrane domain of severe acute respiratory syndrome coronavirus spike glycoprotein are important for receptor-dependent virus entry and cell-cell fusion

  👤 Howard, Megan W. 👤 Travanty, Emily A. 👤 Jeffers, Scott A. 👤 Smith, M. K. 👤 Wennier, Sonia T. 👤 Thackray, Larissa B. 👤 Holmes, Kathryn V. ⏰ 2008 📚 Journal of Virology

• Coronavirus IBV-induced membrane fusion occurs at near-neutral pH

  👤 Li, D. 👤 Cavanagh, D. ⏰ 1992 📚 Archives of Virology

• A single point mutation creating a furin cleavage site in the spike protein renders porcine epidemic diarrhea coronavirus trypsin independent for cell entry and fusion

  👤 Li, Wentao 👤 Wicht, Oliver 👤 van Kuppeveld, Frank J.M. 👤 He, Qigai 👤 Rottier, Peter J.M. 👤 Bosch, Berend Jan ⏰ 2015 📚 Journal of Virology

• Structure-based discovery of Middle East respiratory syndrome coronavirus fusion inhibitor

  👤 Lu, Lu 👤 Liu, Qi 👤 Zhu, Yun 👤 Chan, Kwok Hung 👤 Qin, Lili 👤 Li, Yuan 👤 Wang, Qian 👤 Chan, Jasper Fuk Woo 👤 Du, Lanying 👤 Yu, Fei 👤 Ma, Cuiqing 👤 Ye, Sheng 👤 Yuen, Kwok Yung 👤 Zhang, Rongguang 👤 Jiang, Shibo ⏰ 2014 📚 Nature Communications

• SARS-coronavirus spike S2 domain flanked by cysteine residues C822 and C833 is important for activation of membrane fusion

  👤 Madu, Ikenna G. 👤 Belouzard, Sandrine 👤 Whittaker, Gary R. ⏰ 2009 📚 Virology

• Characterization of a highly conserved domain within the severe acute respiratory syndrome coronavirus spike protein S2 domain with characteristics of a viral fusion peptide

  👤 Madu, Ikenna G. 👤 Roth, Shoshannah L. 👤 Belouzard, Sandrine 👤 Whittaker, Gary R. ⏰ 2009 📚 Journal of Virology

• Efficient activation of the severe acute respiratory syndrome coronavirus spike protein by the transmembrane protease TMPRSS2

  👤 Matsuyama, Shutoku 👤 Nagata, Noriyo 👤 Shirato, Kazuya 👤 Kawase, Miyuki 👤 Takeda, Makoto 👤 Taguchi, Fumihiro ⏰ 2010 📚 Journal of Virology

• Middle east respiratory syndrome coronavirus spike protein is not activated directly by cellular furin during viral entry into target cells

  👤 Matsuyama, Shutoku 👤 Shirato, Kazuya 👤 Kawase, Miyuki 👤 Terada, Yutaka 👤 Kawachi, Kengo 👤 Fukushi, Shuetsu 👤 Kamitani, Wataru ⏰ 2018 📚 Journal of Virology

• Fusion resistance and decreased infectability as major host cell determinants of coronavirus persistence

  👤 Mizzen, Lee 👤 Cheley, Steve 👤 Rao, Meena 👤 Wolf, Robert 👤 Anderson, Robert ⏰ 1983 📚 Virology

• Identification of the fusion peptide-containing region in betacoronavirus spike glycoproteins

  👤 Ou, Xiuyuan 👤 Zheng, Wangliang 👤 Shan, Yiwei 👤 Mu, Zhixia 👤 Dominguez, Samuel R. 👤 Holmes, Kathryn V. 👤 Qian, Zhaohui ⏰ 2016 📚 Journal of Virology

• Neurovirulent murine coronavirus JHM.SD uses cellular zinc metalloproteases for virus entry and cell-cell fusion

  👤 Phillips, Judith M. 👤 Gallagher, Tom 👤 Weiss, Susan R. ⏰ 2017 📚 Journal of Virology

• Endosomal proteolysis by cathepsins is necessary for murine coronavirus mouse hepatitis virus type 2 spike-mediated entry

  👤 Qiu, Zhaozhu 👤 Hingley, Susan T. 👤 Simmons, Graham 👤 Yu, Christopher 👤 Das Sarma, Jayasri 👤 Bates, Paul 👤 Weiss, Susan R. ⏰ 2006 📚 Journal of Virology

• Different host cell proteases activate the SARS-coronavirus spike-protein for cell-cell and virus-cell fusion

  👤 Simmons, Graham 👤 Bertram, Stephanie 👤 Glowacka, Ilona 👤 Steffen, Imke 👤 Chaipan, Chawaree 👤 Agudelo, Juliet 👤 Lu, Kai 👤 Rennekamp, Andrew J. 👤 Hofmann, Heike 👤 Bates, Paul 👤 Pöhlmann, Stefan ⏰ 2011 📚 Virology

• Characterization of severe acute respiratory syndrome-associated coronavirus (SARS-CoV) spike glycoprotein-mediated viral entry

  👤 Simmons, Graham 👤 Reeves, Jacqueline D. 👤 Rennekamp, Andrew J. 👤 Amberg, Sean M. 👤 Piefer, Andrew J. 👤 Bates, Paul ⏰ 2004 📚 Proceedings of the National Academy of Sciences of the United States of America

• Soluble receptor potentiates receptor-independent infection by murine coronavirus

  👤 Taguchi, Fumihiro 👤 Matsuyama, Shutoku ⏰ 2002 📚 Journal of Virology

• Redirecting coronavirus to a nonnative receptor through a virus-encoded targeting adapter

  👤 Verheije, M. H. 👤 Würdinger, T. 👤 Van Beusechem, V. W. 👤 De Haan, C. A.M. 👤 Gerritsen, W. R. 👤 Rottier, P. J.M. ⏰ 2006 📚 Journal of Virology

• The coronavirus spike protein induces endoplasmic reticulum stress and upregulation of intracellular chemokine mRNA concentrations

  👤 Versteeg, Gijs A. 👤 Van De Nes, Paula S. 👤 Bredenbeek, Peter J. 👤 Spaan, Willy J.M. ⏰ 2007 📚 Journal of Virology

• Discovery of Hydrocarbon-Stapled Short α-Helical Peptides as Promising Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Fusion Inhibitors

  👤 Wang, Chao 👤 Xia, Shuai 👤 Zhang, Peiyu 👤 Zhang, Tianhong 👤 Wang, Weicong 👤 Tian, Yangli 👤 Meng, Guangpeng 👤 Jiang, Shibo 👤 Liu, Keliang ⏰ 2018 📚 Journal of Medicinal Chemistry

• Expression cloning of functional receptor used by SARS coronavirus

  👤 Wang, Peigang 👤 Chen, Jian 👤 Zheng, Aihua 👤 Nie, Yuchun 👤 Shi, Xuanling 👤 Wang, Wei 👤 Wang, Guangwen 👤 Luo, Min 👤 Liu, Huijun 👤 Tan, Lei 👤 Song, Xijun 👤 Wang, Zai 👤 Yin, Xiaolei 👤 Qu, Xiuxia 👤 Wang, Xiaojing 👤 Qing, Tingting 👤 Ding, Mingxiao 👤 Deng, Hongkui ⏰ 2004 📚 Biochemical and Biophysical Research Communications

• Inhibition of SARS-CoV-2 (previously 2019-nCoV) infection by a highly potent pan-coronavirus fusion inhibitor targeting its spike protein that harbors a high capacity to mediate membrane fusion.

  👤 Xia, Shuai 👤 Liu, Meiqin 👤 Wang, Chao 👤 Xu, Wei 👤 Lan, Qiaoshuai 👤 Feng, Siliang 👤 Qi, Feifei 👤 Bao, Linlin 👤 Du, Lanying 👤 Liu, Shuwen 👤 Qin, Chuan 👤 Sun, Fei 👤 Shi, Zhengli 👤 Zhu, Yun 👤 Jiang, Shibo 👤 Lu, Lu ⏰ 2020 📚 Cell Res

• Identification of N-linked glycosylation sites in the spike protein and their functional impact on the replication and infectivity of coronavirus infectious bronchitis virus in cell culture

  👤 Zheng, Jie 👤 Yamada, Yoshiyuki 👤 Fung, To Sing 👤 Huang, Mei 👤 Chia, Raymond 👤 Liu, Ding Xiang ⏰ 2018 📚 Virology

• Lysosomal proteases are a determinant of coronavirus tropism

  👤 Zheng, Yuan 👤 Shang, Jian 👤 Yang, Yang 👤 Liu, Chang 👤 Wan, Yushun 👤 Geng, Qibin 👤 Wang, Michelle 👤 Baric, Ralph 👤 Li, Fang ⏰ 2018 📚 Journal of Virology