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🔗 cell-cell fusion (34) 🔗 host cell (262) 🔗 human coronavirus (623) 🔗 results indicate (178) 🔗 important role (140) 🔗 respiratory tract (344) 🔗 sialic acid (42) 🔗 cell culture (240) 🔗 spike protein (353) 🔗 highly pathogenic (100) 🔗 public health (392) 🔗 neutralizing antibodies (122) 🔗 cell lines (125) 🔗 viral particles (45) 🔗 cell line (211) 🔗 syndrome coronavirus (1074) 🔗 respiratory syndrome (2004) 🔗 cells expressing (60) 🔗 fatality rate (123) 🔗 infected cells (307) 🔗 viral entry (91) 🔗 severe acute (1373) 🔗 amino acid (454) 🔗 converting enzyme (162) 🔗 angiotensin-converting enzyme (112) 🔗 acute respiratory (1734) 🔗 amino acids (205) 🔗 determine whether (60) 🔗 membrane fusion (105)

Articles (7)

TMPRSS2 activates the human coronavirus 229E for cathepsin-independent host cell entry and is expressed in viral target cells in the respiratory epithelium
👤 Bertram, Stephanie 👤 Dijkman, Ronald 👤 Habjan, Matthias 👤 Heurich, Adeline 👤 Gierer, Stefanie 👤 Glowacka, Ilona 👤 Welsch, Kathrin 👤 Winkler, Michael 👤 Schneider, Heike 👤 Hofmann-Winkler, Heike 👤 Volker Thiel, None 👤 Pöhlmann, Stefan ⏰ 2013 📚 Journal of Virology
Influenza and SARS-coronavirus activating proteases TMPRSS2 and HAT are expressed at multiple sites in human respiratory and gastrointestinal tracts
👤 Bertram, Stephanie 👤 Heurich, Adeline 👤 Lavender, Hayley 👤 Gierer, Stefanie 👤 Danisch, Simon 👤 Perin, Paula 👤 Lucas, Jared M. 👤 Nelson, Peter S. 👤 Pöhlmann, Stefan 👤 Soilleux, Elizabeth J. ⏰ 2012 📚 PLoS ONE
The spike protein of the emerging betacoronavirus EMC uses a novel coronavirus receptor for entry, can be activated by TMPRSS2, and is targeted by neutralizing antibodies
👤 Gierer, Stefanie 👤 Bertram, Stephanie 👤 Kaup, Franziska 👤 Wrensch, Florian 👤 Heurich, Adeline 👤 Krämer-Kühl, Annika 👤 Welsch, Kathrin 👤 Winkler, Michael 👤 Meyer, Benjamin 👤 Drosten, Christian 👤 Dittmer, Ulf 👤 von Hahn, Thomas 👤 Simmons, Graham 👤 Hofmann, Heike 👤 Pöhlmann, Stefan ⏰ 2013 📚 Journal of Virology
Lack of MERS coronavirus neutralizing antibodies in humans, Eastern Province, Saudi Arabia
👤 Gierer, Stefanie 👤 Hofmann-Winkler, Heike 👤 Albuali, Waleed H. 👤 Bertram, Stephanie 👤 Al-Rubaish, Abdullah M. 👤 Yousef, Abdullah A. 👤 Al-Nafaie, Awatif N. 👤 Al-Ali, Amein K. 👤 Obeid, Obeid E. 👤 Alkharsah, Khaled R. 👤 Pöhlmann, Stefan ⏰ 2013 📚 Emerging Infectious Diseases
Inhibition of proprotein convertases abrogates processing of the middle eastern respiratory syndrome coronavirus spike protein in infected cells but does not reduce viral infectivity
👤 Gierer, Stefanie 👤 Müller, Marcel A. 👤 Heurich, Adeline 👤 Ritz, Daniel 👤 Springstein, Benjamin L. 👤 Karsten, Christina B. 👤 Schendzielorz, Alexander 👤 Gnirß, Kerstin 👤 Drosten, Christian 👤 Pöhlmann, Stefan ⏰ 2015 📚 Journal of Infectious Diseases
TMPRSS2 and ADAM17 cleave ACE2 differentially and only proteolysis by TMPRSS2 augments entry driven by the severe acute respiratory syndrome coronavirus spike protein
👤 Heurich, Adeline 👤 Hofmann-Winkler, Heike 👤 Gierer, Stefanie 👤 Liepold, Thomas 👤 Jahn, Olaf 👤 Pöhlmann, Stefan ⏰ 2014 📚 Journal of Virology
Proteolytic activation of the SARS-coronavirus spike protein: Cutting enzymes at the cutting edge of antiviral research
👤 Simmons, Graham 👤 Zmora, Pawel 👤 Gierer, Stefanie 👤 Heurich, Adeline 👤 Pöhlmann, Stefan ⏰ 2013 📚 Antiviral Research