📄 Human coronavirus 229E: Receptor binding domain and neutralization by soluble receptor at 37°C

Truncated human coronavirus HCoV-229E spike glycoproteins containing amino acids 407 to 547 bound to purified, soluble virus receptor, human aminopeptidase N (hAPN). Soluble hAPN neutralized the infectivity of HCoV-229E virions at 37°C, but not 4°C. Binding of hAPN may therefore trigger conformational changes in the viral spike protein at 37°C that facilitate virus entry.

keywords 🔗 spike protein (353) 🔗 amino acid (454) 🔗 human coronavirus (623) 🔗 spike glycoprotein (99) 🔗 amino acids (205)

download 🔖 [BibTeX]