📄 Mouse dipeptidyl peptidase 4 is not a functional receptor for middle east respiratory syndrome coronavirus infection

Human dipeptidyl peptidase 4 (hDPP4) was recently identified as the receptor for Middle East respiratory syndrome coronavirus (MERS-CoV) infection, suggesting that other mammalian DPP4 orthologs may also support infection. We demonstrate that mouse DPP4 cannot support MERS-CoV infection. However, employing mouse DPP4 as a scaffold, we identified two critical amino acids (A288L and T330R) that regulate species specificity in the mouse. This knowledge can support the rational design of a mouse-adapted MERS-CoV for rapid assessment of therapeutics. © 2014, American Society for Microbiology.

keywords 🔗 syndrome coronavirus (1074) 🔗 amino acid (454) 🔗 dipeptidyl peptidase (47) 🔗 respiratory syndrome (2004) 🔗 amino acids (205)

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