The spike glycoprotein of the new coronavirus 2019-nCoV contains a furin-like cleavage site absent in CoV of the same clade.

In 2019, a new coronavirus (2019-nCoV) infecting Humans has emerged in Wuhan, China. Its genome has been sequenced and the genomic information promptly released. Despite a high similarity with the genome sequence of SARS-CoV and SARS-like Co. Vs, we identified a peculiar furin-like cleavage site in the Spike protein of the 2019-nCoV, lacking in the other SARS-like Co. Vs. In this article, we discuss the possible functional consequences of this cleavage site in the viral cycle, pathogenicity and its potential implication in the development of antivirals.

keywords 🔗 *2019-nCoV (257) 🔗 *Antivirals (61) 🔗 *Furin () 🔗 *Maturation protease () 🔗 *SARS-CoV (1685) 🔗 *Spike protein (353) 🔗 cleavage site (85) 🔗 genome sequence (133)

author 👤 Coutard, B 👤 Valle, C 👤 de Lamballerie, X 👤 Canard, B 👤 Seidah, N G 👤 Decroly, E

year ⏰ 2020

journal 📚 Antiviral Res

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doi 📄 10.1016/j.antiviral.2020.104742 ⤴

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