🔗 Antivirals

Articles (61)

• Coronavirus susceptibility to the antiviral remdesivir (GS-5734) is mediated by the viral polymerase and the proofreading exoribonuclease

  👤 Agostini, Maria L. 👤 Andres, Erica L. 👤 Sims, Amy C. 👤 Graham, Rachel L. 👤 Sheahan, Timothy P. 👤 Lu, Xiaotao 👤 Smith, Everett Clinton 👤 Case, James Brett 👤 Feng, Joy Y. 👤 Jordan, Robert 👤 Ray, Adrian S. 👤 Cihlar, Tomas 👤 Siegel, Dustin 👤 Mackman, Richard L. 👤 Clarke, Michael O. 👤 Baric, Ralph S. 👤 Denison, Mark R. ⏰ 2018 📚 mBio

• Small-Molecule Antiviral β-d-N4-Hydroxycytidine Inhibits a Proofreading-Intact Coronavirus with a High Genetic Barrier to Resistance

  👤 Agostini, Maria L. 👤 Pruijssers, Andrea J. 👤 Chappell, James D. 👤 Gribble, Jennifer 👤 Lu, Xiaotao 👤 Andres, Erica L. 👤 Bluemling, Gregory R. 👤 Lockwood, Mark A. 👤 Sheahan, Timothy P. 👤 Sims, Amy C. 👤 Natchus, Michael G. 👤 Saindane, Manohar 👤 Kolykhalov, Alexander A. 👤 Painter, George R. 👤 Baric, Ralph S. 👤 Denison, Mark R. ⏰ 2019 📚 Journal of virology

• Development of broad-spectrum halomethyl ketone inhibitors against coronavirus main protease 3CLpro

  👤 Bacha, Usman 👤 Barrila, Jennifer 👤 Gabelli, Sandra B. 👤 Kiso, Yoshiaki 👤 Mario Amzel, L. 👤 Freire, Ernesto ⏰ 2008 📚 Chemical Biology and Drug Design

• Molecular Pathogenesis of Middle East Respiratory Syndrome (MERS) Coronavirus

  👤 Banerjee, Arinjay 👤 Baid, Kaushal 👤 Mossman, Karen ⏰ 2019 📚 Current Clinical Microbiology Reports

• A Comparative Review of Animal Models of Middle East Respiratory Syndrome Coronavirus Infection

  👤 Baseler, L. 👤 de Wit, E. 👤 Feldmann, H. ⏰ 2016 📚 Veterinary Pathology

• Overview of current therapeutics and novel candidates against influenza, respiratory syncytial virus, and Middle East respiratory syndrome coronavirus infections

  👤 Behzadi, Mohammad Amin 👤 Leyva-Grado, Victor H. ⏰ 2019 📚 Frontiers in Microbiology

• Three amino acid changes in avian coronavirus spike protein allow binding to kidney tissue

  👤 Bouwman, Kim M. 👤 Parsons, Lisa M. 👤 Berends, Alinda J. 👤 De Vries, Robert P. 👤 Cipollo, John F. 👤 Verheije, Monique H. ⏰ 2020 📚 Journal of Virology

• Computational inference of selection underlying the evolution of the novel coronavirus, SARS-CoV-2.

  👤 Cagliani, Rachele 👤 Forni, Diego 👤 Clerici, Mario 👤 Sironi, Manuela ⏰ 2020 📚 J Virol

• Recommendations for coronavirus infection in rheumatic diseases treated with biologic therapy.

  👤 Ceribelli, Angela 👤 Motta, Francesca 👤 De Santis, Maria 👤 Ansari, Aftab A 👤 Ridgway, William M 👤 Gershwin, M Eric 👤 Selmi, Carlo ⏰ 2020 📚 J Autoimmun

• Broad-spectrum antivirals for the emerging Middle East respiratory syndrome coronavirus

  👤 Chan, Jasper F.W. 👤 Chan, Kwok Hung 👤 Kao, Richard Y.T. 👤 To, Kelvin K.W. 👤 Zheng, Bo Jian 👤 Li, Clara P.Y. 👤 Li, Patrick T.W. 👤 Dai, Jun 👤 Mok, Florence K.Y. 👤 Chen, Honglin 👤 Hayden, Frederick G. 👤 Yuen, Kwok Yung ⏰ 2013 📚 Journal of Infection

• Middle East Respiratory syndrome coronavirus: Another zoonotic betacoronavirus causing SARS-like disease

  👤 Chan, Jasper F.W. 👤 Lau, Susanna K.P. 👤 To, Kelvin K.W. 👤 Cheng, Vincent C.C. 👤 Woo, Patrick C.Y. 👤 Yue, Kwok Yung ⏰ 2015 📚 Clinical Microbiology Reviews

• Functional screen reveals SARS coronavirus nonstructural protein nsp14 as a novel cap N7 methyltransferase

  👤 Chen, Yu 👤 Cai, Hui 👤 Pan, Ji'an 👤 Xiang, Nian 👤 Tien, Po 👤 Ahola, Tero 👤 Guo, Deyin ⏰ 2009 📚 Proceedings of the National Academy of Sciences of the United States of America

• Prediction of the SARS-CoV-2 (2019-nCoV) 3C-like protease (3CL (pro)) structure: virtual screening reveals velpatasvir, ledipasvir, and other drug repurposing candidates.

  👤 Chen, Yu Wai 👤 Yiu, Chin-Pang Bennu 👤 Wong, Kwok-Yin ⏰ 2020 📚 F1000Res

• Severe acute respiratory syndrome coronavirus as an agent of emerging and reemerging infection

  👤 Cheng, Vincent C.C. 👤 Lau, Susanna K.P. 👤 Woo, Patrick C.Y. 👤 Kwok, Yung Yuen ⏰ 2007 📚 Clinical Microbiology Reviews

• The spike glycoprotein of the new coronavirus 2019-nCoV contains a furin-like cleavage site absent in CoV of the same clade.

  👤 Coutard, B 👤 Valle, C 👤 de Lamballerie, X 👤 Canard, B 👤 Seidah, N G 👤 Decroly, E ⏰ 2020 📚 Antiviral Res

• Potential antivirals and antiviral strategies against SARS coronavirus infections

  👤 De Clercq, Erik ⏰ 2006 📚 Expert Review of Anti-Infective Therapy

• Inhibition of NF-κB-mediated inflammation in severe acute respiratory syndrome coronavirus-infected mice increases survival

  👤 DeDiego, Marta L. 👤 Nieto-Torres, Jose L. 👤 Regla-Nava, Jose A. 👤 Jimenez-Guardeño, Jose M. 👤 Fernandez-Delgado, Raul 👤 Fett, Craig 👤 Castaño-Rodriguez, Carlos 👤 Perlman, Stanley 👤 Enjuanes, Luis ⏰ 2014 📚 Journal of Virology

• Discovering drugs to treat coronavirus disease 2019 (COVID-19).

  👤 Dong, Liying 👤 Hu, Shasha 👤 Gao, Jianjun ⏰ 2020 📚 Drug Discov Ther

• Tilorone: a Broad-Spectrum Antiviral Invented in the USA and Commercialized in Russia and beyond.

  👤 Ekins, Sean 👤 Lane, Thomas R 👤 Madrid, Peter B ⏰ 2020 📚 Pharm Res

• The origin, transmission and clinical therapies on coronavirus disease 2019 (COVID-19) outbreak - an update on the status.

  👤 Guo, Yan-Rong 👤 Cao, Qing-Dong 👤 Hong, Zhong-Si 👤 Tan, Yuan-Yang 👤 Chen, Shou-Deng 👤 Jin, Hong-Jun 👤 Tan, Kai-Sen 👤 Wang, De-Yun 👤 Yan, Yan ⏰ 2020 📚 Mil Med Res

• Application of real-time PCR for testing antiviral compounds against Lassa virus, SARS coronavirus and Ebola virus in vitro

  👤 Günther, Stephan 👤 Asper, Marcel 👤 Röser, Christina 👤 Luna, Luciano K.S. 👤 Drosten, Christian 👤 Becker-Ziaja, Beate 👤 Borowski, Peter 👤 Chen, Huan Ming 👤 Hosmane, Ramachandra S. ⏰ 2004 📚 Antiviral Research

• Coronaviruses and their therapy

  👤 Haagmans, Bart L. 👤 Osterhaus, Albert D.M.E. ⏰ 2006 📚 Antiviral Research

• Interferon-β and mycophenolic acid are potent inhibitors of middle east respiratory syndrome coronavirus in cell-based assays

  👤 Hart, Brit J. 👤 Dyall, Julie 👤 Postnikova, Elena 👤 Zhou, Huanying 👤 Kindrachuk, Jason 👤 Johnson, Reed F. 👤 Olinger Jr., Gene G. 👤 Frieman, Matthew B. 👤 Holbrook, Michael R. 👤 Jahrling, Peter B. 👤 Hensley, Lisa ⏰ 2014 📚 Journal of General Virology

• From SARS to MERS: crystallographic studies on coronaviral proteases enable antiviral drug design

  👤 Hilgenfeld, Rolf ⏰ 2014 📚 The FEBS journal

• Coronaviruses and the human airway: A universal system for virus-host interaction studies Coronaviruses: Emerging and re-emerging pathogens in humans and animals Susanna Lau Emerging viruses

  👤 Jonsdottir, Hulda R. 👤 Dijkman, Ronald ⏰ 2016 📚 Virology Journal

• The 2019 Novel Coronavirus Outbreak - A Global Threat.

  👤 Khot, Wasim Yunus 👤 Nadkar, Milind Y ⏰ 2020 📚 J Assoc Physicians India

• Cell-based antiviral screening against coronaviruses: Developing virus-specific and broad-spectrum inhibitors

  👤 Kilianski, Andy 👤 Baker, Susan C. ⏰ 2014 📚 Antiviral Research

• 2,6-Bis-arylmethyloxy-5-hydroxychromones with antiviral activity against both hepatitis C virus (HCV) and SARS-associated coronavirus (SCV)

  👤 Kim, Mi Kyoung 👤 Yu, Mi Sun 👤 Park, Hye Ri 👤 Kim, Kyung Bo 👤 Lee, Chaewoon 👤 Cho, Suh Young 👤 Kang, Jihoon 👤 Yoon, Hyunjun 👤 Kim, Dong Eun 👤 Choo, Hyunah 👤 Jeong, Yong Joo 👤 Chong, Youhoon ⏰ 2011 📚 European Journal of Medicinal Chemistry

• Broad-spectrum antivirals against 3C or 3C-like proteases of picornaviruses, noroviruses, and coronaviruses

  👤 Kim, Yunjeong 👤 Lovell, Scott 👤 Tiew, Kok Chuan 👤 Mandadapu, Sivakoteswara Rao 👤 Alliston, Kevin R. 👤 Battaile, Kevin K. 👤 Groutas, William C. 👤 Chang, Kyeong Ok ⏰ 2012 📚 Journal of Virology

• Alternative screening approaches for discovery of Middle East respiratory syndrome coronavirus inhibitors

  👤 La Femina, Robert L. ⏰ 2014 📚 Antimicrobial Agents and Chemotherapy

• Crystal structure of the papain-like protease of MERS coronavirus reveals unusual, potentially druggable active-site features

  👤 Lei, Jian 👤 Mesters, Jeroen R. 👤 Drosten, Christian 👤 Anemüller, Stefan 👤 Ma, Qingjun 👤 Hilgenfeld, Rolf ⏰ 2014 📚 Antiviral Research

• Molecular mapping of the RNA cap 2′-O-methyltransferase activation interface between severe acute respiratory syndrome coronavirus nsp10 and nsp16

  👤 Lugari, Adrien 👤 Betzi, Stephane 👤 Decroly, Etienne 👤 Bonnaud, Emmanuel 👤 Hermant, Aurélie 👤 Guillemot, Jean Claude 👤 Debarnot, Claire 👤 Borg, Jean Paul 👤 Bouvet, Mickaël 👤 Canard, Bruno 👤 Morelli, Xavier 👤 Lécine, Patrick ⏰ 2010 📚 Journal of Biological Chemistry

• Potential Effects of Coronaviruses on the Cardiovascular System: A Review.

  👤 Madjid, Mohammad 👤 Safavi-Naeini, Payam 👤 Solomon, Scott D 👤 Vardeny, Orly ⏰ 2020 📚 JAMA Cardiol

• The genome sequence of the SARS-associated coronavirus

  👤 Marra, Marco A. 👤 Jones, Steven J.M. 👤 Astell, Caroline R. 👤 Holt, Robert A. 👤 Brooks-Wilson, Angela 👤 Butterfield, Yaron S.N. 👤 Khattra, Jaswinder 👤 Asano, Jennifer K. 👤 Barber, Sarah A. 👤 Chan, Susanna Y. 👤 Cloutier, Alison 👤 Coughlin, Shaun M. 👤 Freeman, Doug 👤 Girn, Noreen 👤 Griffith, Obi L. 👤 Leach, Stephen R. 👤 Mayo, Michael 👤 McDonald, Helen 👤 Montgomery, Stephen B. 👤 Pandoh, Pawan K. 👤 Petrescu, Anca S. 👤 Robertson, A. Gordon 👤 Schein, Jacqueline E. 👤 Siddiqui, Asim 👤 Smailus, Duane E. 👤 Stott, Jeff M. 👤 Yang, George S. 👤 Plummer, Francis 👤 Andonov, Anton 👤 Artsob, Harvey 👤 Bastien, Nathatie 👤 Bernard, Kathy 👤 Booth, Timothy F. 👤 Bowness, Donnie 👤 Czub, Martin 👤 Drebot, Michael 👤 Fernando, Lisa 👤 Flick, Ramon 👤 Garbutt, Michael 👤 Gray, Michael 👤 Grolla, Allen 👤 Jones, Steven 👤 Feldmann, Heinz 👤 Meyers, Adrienne 👤 Kabani, Amin 👤 Li, Yan 👤 Normand, Susan 👤 Stroher, Ute 👤 Tipples, Graham A. 👤 Tyler, Shaun 👤 Vogrig, Robert 👤 Ward, Diane 👤 Watson, Brynn 👤 Brunham, Robert C. 👤 Krajden, Mel 👤 Petric, Martin 👤 Skowronski, Danuta M. 👤 Upton, Chris 👤 Roper, Rachel L. ⏰ 2003 📚 Science

• Inhibition of stress granule formation by middle east respiratory syndrome coronavirus 4a accessory protein facilitates viral translation, leading to efficient virus replication

  👤 Nakagawa, Keisuke 👤 Narayanan, Krishna 👤 Wada, Masami 👤 Makino, Shinji ⏰ 2018 📚 Journal of Virology

• Unrevealing sequence and structural features of novel coronavirus using in silico approaches: The main protease as molecular target.

  👤 Ortega, Joseph Thomas 👤 Serrano, Maria Luisa 👤 Pujol, Flor Helene 👤 Rangel, Hector Rafael ⏰ 2020 📚 EXCLI J

• New antiviral drugs, vaccines and classic public health interventions against SARS coronavirus

  👤 Oxford, John S. 👤 Balasingam, Shobana 👤 Chan, Charlotte 👤 Catchpole, Andrew 👤 Lambkin, Robert ⏰ 2005 📚 Antiviral Chemistry and Chemotherapy

• Potential Rapid Diagnostics, Vaccine and Therapeutics for 2019 Novel Coronavirus (2019-nCoV): A Systematic Review.

  👤 Pang, Junxiong 👤 Wang, Min Xian 👤 Ang, Ian Yi Han 👤 Tan, Sharon Hui Xuan 👤 Lewis, Ruth Frances 👤 Chen, Jacinta I-Pei 👤 Gutierrez, Ramona A 👤 Gwee, Sylvia Xiao Wei 👤 Chua, Pearleen Ee Yong 👤 Yang, Qian 👤 Ng, Xian Yi 👤 Yap, Rowena Ks 👤 Tan, Hao Yi 👤 Teo, Yik Ying 👤 Tan, Chorh Chuan 👤 Cook, Alex R 👤 Yap, Jason Chin-Huat 👤 Hsu, Li Yang ⏰ 2020 📚 J Clin Med

• Avoiding regions symptomatic of conformational and functional flexibility to identify antiviral targets in current and future coronaviruses

  👤 Rahaman, Jordon 👤 Siltberg-Liberles, Jessica ⏰ 2016 📚 Genome Biology and Evolution

• Structural Bases of Coronavirus Attachment to Host Aminopeptidase N and Its Inhibition by Neutralizing Antibodies

  👤 Reguera, Juan 👤 Santiago, César 👤 Mudgal, Gaurav 👤 Ordoño, Desiderio 👤 Enjuanes, Luis 👤 Casasnovas, José M. ⏰ 2012 📚 PLoS Pathogens

• A mouse-adapted SARS-coronavirus causes disease and mortality in BALB/c mice

  👤 Roberts, Anjeanette 👤 Deming, Damon 👤 Paddock, Christopher D. 👤 Cheng, Aaron 👤 Yount, Boyd 👤 Vogel, Leatrice 👤 Herman, Brian D. 👤 Sheahan, Tim 👤 Heise, Mark 👤 Genrich, Gillian L. 👤 Zaki, Sherif R. 👤 Baric, Ralph 👤 Subbarao, Kanta ⏰ 2007 📚 PLoS Pathogens

• Severe acute respiratory syndrome coronavirus infection of Golden Syrian hamsters

  👤 Roberts, Anjeanette 👤 Vogel, Leatrice 👤 Guarner, Jeannette 👤 Hayes, Norman 👤 Murphy, Brian 👤 Zaki, Sherif 👤 Subbarao, Kanta ⏰ 2005 📚 Journal of Virology

• Nitazoxanide, a new drug candidate for the treatment of Middle East respiratory syndrome coronavirus

  👤 Rossignol, Jean François ⏰ 2016 📚 Journal of Infection and Public Health

• Structural Genomics of SARS-CoV-2 Indicates Evolutionary Conserved Functional Regions of Viral Proteins.

  👤 Srinivasan, Suhas 👤 Cui, Hongzhu 👤 Gao, Ziyang 👤 Liu, Ming 👤 Lu, Senbao 👤 Mkandawire, Winnie 👤 Narykov, Oleksandr 👤 Sun, Mo 👤 Korkin, Dmitry ⏰ 2020 📚 Viruses

• Characterization and demonstration of the value of a lethal mouse model of Middle East respiratory syndrome coronavirus infection and disease

  👤 Tao, Xinrong 👤 Garron, Tania 👤 Agrawal, Anurodh Shankar 👤 Algaissi, Abdullah 👤 Peng, Bi Hung 👤 Wakamiya, Maki 👤 Chan, Teh Sheng 👤 Lu, Lu 👤 Du, Lanying 👤 Jiang, Shibo 👤 Couch, Robert B. 👤 Tseng, Chien Te K. ⏰ 2016 📚 Journal of Virology

• Multisite inhibitors for enteric coronavirus: antiviral cationic carbon dots based on curcumin

  👤 Ting, Du 👤 Dong, Nan 👤 Fang, Liurong 👤 Lu, Jian 👤 Bi, Jing 👤 Xiao, Shaobo 👤 Han, Heyou ⏰ 2018 📚 ACS Applied Nano Materials

• Therapies for coronaviruses. Part 2: Inhibitors of intracellular life cycle

  👤 Tong, Tommy R. ⏰ 2009 📚 Expert Opinion on Therapeutic Patents

• Therapies for coronaviruses. Part I of II - Viral entry inhibitors

  👤 Tong, Tommy R. ⏰ 2009 📚 Expert Opinion on Therapeutic Patents

• Protein-protein interactions of viroporins in coronaviruses and paramyxoviruses: New targets for antivirals?

  👤 Torres, Jaume 👤 Surya, Wahyu 👤 Li, Yan 👤 Liu, Ding Xiang ⏰ 2015 📚 Viruses

• Severe acute respiratory syndrome coronavirus infection of mice transgenic for the human angiotensin-converting enzyme 2 virus receptor

  👤 Tseng, Chien Te K. 👤 Huang, Cheng 👤 Newman, Patrick 👤 Wang, Nan 👤 Narayanan, Krishna 👤 Watts, Douglas M. 👤 Makino, Shinji 👤 Packard, Michelle M. 👤 Zaki, Sherif R. 👤 Chan, Teh Sheng 👤 Peters, Clarence J. ⏰ 2007 📚 Journal of Virology

• Searching for animal models and potential target species for emerging pathogens: Experience gained from Middle East respiratory syndrome (MERS) coronavirus

  👤 Vergara-Alert, Júlia 👤 Vidal, Enric 👤 Bensaid, Albert 👤 Segalés, Joaquim ⏰ 2017 📚 One Health

• Structural and biochemical characterization of SADS-CoV papain-like protease 2.

  👤 Wang, Lu 👤 Hu, Weihua 👤 Fan, Chengpeng ⏰ 2020 📚 Protein Sci

• Subunit Vaccines Against Emerging Pathogenic Human Coronaviruses.

  👤 Wang, Ning 👤 Shang, Jian 👤 Jiang, Shibo 👤 Du, Lanying ⏰ 2020 📚 Front Microbiol

• Antiviral activity of Sambucus FormosanaNakai ethanol extract and related phenolic acid constituents against human coronavirus NL63

  👤 Weng, Jing Ru 👤 Lin, Chen Sheng 👤 Lai, Hsueh Chou 👤 Lin, Yu Ping 👤 Wang, Ching Ying 👤 Tsai, Yu Chi 👤 Wu, Kun Chang 👤 Huang, Su Hua 👤 Lin, Cheng Wen ⏰ 2019 📚 Virus Research

• Elevated plasma surfactant protein d (sp-d) levels and a direct correlation with anti-severe acute respiratory syndrome coronavirus-specific igg antibody in sars patients

  👤 Wu, Y. P. 👤 Liu, Z. H. 👤 Wei, R. 👤 Pan, S. D. 👤 Mao, N. Y. 👤 Chen, B. 👤 Han, J. J. 👤 Zhang, F. S. 👤 Holmskov, U. 👤 Xia, Z. L. 👤 De Groot, P. G. 👤 Reid, K. B.M. 👤 Xu, W. B. 👤 Sorensen, G. L. ⏰ 2009 📚 Scandinavian Journal of Immunology

• An animal model of mers produced by infection of rhesus macaques with MERS coronavirus

  👤 Yao, Yanfeng 👤 Bao, Linlin 👤 Deng, Wei 👤 Xu, Lili 👤 Li, Fengdi 👤 Lv, Qi 👤 Yu, Pin 👤 Chen, Ting 👤 Xu, Yanfeng 👤 Zhu, Hua 👤 Yuan, Jing 👤 Gu, Songzhi 👤 Wei, Qiang 👤 Chen, Honglin 👤 Yuen, Kwok Yung 👤 Qin, Chuan ⏰ 2014 📚 Journal of Infectious Diseases

• Antiviral effect of lithium chloride and diammonium glycyrrhizinate on porcine deltacoronavirus in vitro

  👤 Zhai, Xiaofeng 👤 Wang, Shilei 👤 Zhu, Mengyan 👤 He, Wei 👤 Pan, Zhongzhou 👤 Su, Shuo ⏰ 2019 📚 Pathogens

• A novel nanobody targeting middle east respiratory syndrome coronavirus (MERS-CoV) receptor-binding domain has potent cross-neutralizing activity and protective efficacy against MERS-CoV

  👤 Zhao, Guangyu 👤 He, Lei 👤 Sun, Shihui 👤 Qiu, Hongjie 👤 Tai, Wanbo 👤 Chen, Jiawei 👤 Li, Jiangfan 👤 Chen, Yuehong 👤 Guo, Yan 👤 Wang, Yufei 👤 Shang, Jian 👤 Ji, Kaiyuan 👤 Fan, Ruiwen 👤 Du, Enqi 👤 Jiang, Shibo 👤 Li, Fang 👤 Du, Lanying 👤 Zhou, Yusen ⏰ 2018 📚 Journal of Virology

• Structure of the main protease from a global infectious human coronavirus, HCoV-HKU1

  👤 Zhao, Qi 👤 Li, Shuang 👤 Xue, Fei 👤 Zou, Yilong 👤 Chen, Cheng 👤 Bartlam, Mark 👤 Rao, Zihe ⏰ 2008 📚 Journal of Virology

• Coronavirus disease 2019 (COVID-19): a clinical update.

  👤 Zhou, Min 👤 Zhang, Xinxin 👤 Qu, Jieming ⏰ 2020 📚 Front Med

• Protease inhibitors targeting coronavirus and filovirus entry

  👤 Zhou, Yanchen 👤 Vedantham, Punitha 👤 Lu, Kai 👤 Agudelo, Juliet 👤 Carrion, Ricardo 👤 Nunneley, Jerritt W. 👤 Barnard, Dale 👤 Pöhlmann, Stefan 👤 McKerrow, James H. 👤 Renslo, Adam R. 👤 Simmons, Graham ⏰ 2015 📚 Antiviral Research