👤 Lu, Xiaotao

Keywords

Articles (11)

• Coronavirus susceptibility to the antiviral remdesivir (GS-5734) is mediated by the viral polymerase and the proofreading exoribonuclease

  👤 Agostini, Maria L. 👤 Andres, Erica L. 👤 Sims, Amy C. 👤 Graham, Rachel L. 👤 Sheahan, Timothy P. 👤 Lu, Xiaotao 👤 Smith, Everett Clinton 👤 Case, James Brett 👤 Feng, Joy Y. 👤 Jordan, Robert 👤 Ray, Adrian S. 👤 Cihlar, Tomas 👤 Siegel, Dustin 👤 Mackman, Richard L. 👤 Clarke, Michael O. 👤 Baric, Ralph S. 👤 Denison, Mark R. ⏰ 2018 📚 mBio

• Small-Molecule Antiviral β-d-N4-Hydroxycytidine Inhibits a Proofreading-Intact Coronavirus with a High Genetic Barrier to Resistance

  👤 Agostini, Maria L. 👤 Pruijssers, Andrea J. 👤 Chappell, James D. 👤 Gribble, Jennifer 👤 Lu, Xiaotao 👤 Andres, Erica L. 👤 Bluemling, Gregory R. 👤 Lockwood, Mark A. 👤 Sheahan, Timothy P. 👤 Sims, Amy C. 👤 Natchus, Michael G. 👤 Saindane, Manohar 👤 Kolykhalov, Alexander A. 👤 Painter, George R. 👤 Baric, Ralph S. 👤 Denison, Mark R. ⏰ 2019 📚 Journal of virology

• Coronavirus replicase-reporter fusions provide quantitative analysis of replication and replication complex formation

  👤 Freeman, Megan Culler 👤 Graham, Rachel L. 👤 Lu, Xiaotao 👤 Peek, Christopher T. 👤 Denison, Mark R. ⏰ 2014 📚 Journal of Virology

• Fitness barriers limit reversion of a proofreading-deficient coronavirus

  👤 Graepel, Kevin W. 👤 Agostini, Maria L. 👤 Lu, Xiaotao 👤 Sexton, Nicole R. 👤 Denisona, Mark R. ⏰ 2019 📚 Journal of Virology

• Proofreading-deficient coronaviruses adapt for increased fitness over long-term passage without reversion of exoribonuclease-inactivating mutations

  👤 Graepel, Kevin W. 👤 Lu, Xiaotao 👤 Case, James Brett 👤 Sexton, Nicole R. 👤 Smith, Everett Clinton 👤 Denisona, Mark R. ⏰ 2017 📚 mBio

• Coronavirus protein processing and RNA synthesis is inhibited by the cysteine proteinase inhibitor E64d

  👤 Kim, James C. 👤 Spence, Robert A. 👤 Currier, Paul F. 👤 Lu, Xiaotao 👤 Denison, Mark R. ⏰ 1995 📚 Virology

• Intracellular and in vitro-translated 27-kDa proteins contain the 3C-like proteinase activity of the coronavirus MHV-A59

  👤 Lu, Xiaotao 👤 Lu, Yiqi 👤 Denison, Mark R. ⏰ 1996 📚 Virology

• Identification and characterization of severe acute respiratory syndrome coronavirus replicase proteins

  👤 Prentice, Erik 👤 McAuliffe, Josephine 👤 Lu, Xiaotao 👤 Subbarao, Kanta 👤 Denison, Mark R. ⏰ 2004 📚 Journal of Virology

• An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 in human airway epithelial cell cultures and multiple coronaviruses in mice.

  👤 Sheahan, Timothy P 👤 Sims, Amy C 👤 Zhou, Shuntai 👤 Graham, Rachel L 👤 Pruijssers, Andrea J 👤 Agostini, Maria L 👤 Leist, Sarah R 👤 Schafer, Alexandra 👤 Dinnon, Kenneth H 3rd 👤 Stevens, Laura J 👤 Chappell, James D 👤 Lu, Xiaotao 👤 Hughes, Tia M 👤 George, Amelia S 👤 Hill, Collin S 👤 Montgomery, Stephanie A 👤 Brown, Ariane J 👤 Bluemling, Gregory R 👤 Natchus, Michael G 👤 Saindane, Manohar 👤 Kolykhalov, Alexander A 👤 Painter, George 👤 Harcourt, Jennifer 👤 Tamin, Azaibi 👤 Thornburg, Natalie J 👤 Swanstrom, Ronald 👤 Denison, Mark R 👤 Baric, Ralph S ⏰ 2020 📚 Sci Transl Med

• Temperature-sensitive mutants and revertants in the coronavirus nonstructural protein 5 protease (3CLpro) define residues involved in long-distance communication and regulation of protease activity

  👤 Stobart, Christopher C. 👤 Lee, Alice S. 👤 Lu, Xiaotao 👤 Denisona, Mark R. ⏰ 2012 📚 Journal of Virology

• Chimeric exchange of coronavirus nsp5 proteases (3CLpro) identifies common and divergent regulatory determinants of protease activity

  👤 Stobart, Christopher C. 👤 Sexton, Nicole R. 👤 Munjal, Havisha 👤 Lu, Xiaotao 👤 Molland, Katrina L. 👤 Tomar, Sakshi 👤 Mesecar, Andrew D. 👤 Denison, Mark R. ⏰ 2013 📚 Journal of Virology