π€ Sims, Amy C.
Keywords
Articles (20)
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Coronavirus susceptibility to the antiviral remdesivir (GS-5734) is mediated by the viral polymerase and the proofreading exoribonuclease
π€ Agostini, Maria L. π€ Andres, Erica L. π€ Sims, Amy C. π€ Graham, Rachel L. π€ Sheahan, Timothy P. π€ Lu, Xiaotao π€ Smith, Everett Clinton π€ Case, James Brett π€ Feng, Joy Y. π€ Jordan, Robert π€ Ray, Adrian S. π€ Cihlar, Tomas π€ Siegel, Dustin π€ Mackman, Richard L. π€ Clarke, Michael O. π€ Baric, Ralph S. π€ Denison, Mark R. β° 2018 π mBio
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Small-Molecule Antiviral Ξ²-d-N4-Hydroxycytidine Inhibits a Proofreading-Intact Coronavirus with a High Genetic Barrier to Resistance
π€ Agostini, Maria L. π€ Pruijssers, Andrea J. π€ Chappell, James D. π€ Gribble, Jennifer π€ Lu, Xiaotao π€ Andres, Erica L. π€ Bluemling, Gregory R. π€ Lockwood, Mark A. π€ Sheahan, Timothy P. π€ Sims, Amy C. π€ Natchus, Michael G. π€ Saindane, Manohar π€ Kolykhalov, Alexander A. π€ Painter, George R. π€ Baric, Ralph S. π€ Denison, Mark R. β° 2019 π Journal of virology
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Synthetic recombinant bat SARS-like coronavirus is infectious in cultured cells and in mice
π€ Becker, Michelle M. π€ Graham, Rachel L. π€ Donaldson, Eric F. π€ Rockx, Barry π€ Sims, Amy C. π€ Sheahan, Timothy π€ Pickles, Raymond J. π€ Corti, Davide π€ Johnston, Robert E. π€ Baric, Ralph S. π€ Denison, Mark R. β° 2008 π Proceedings of the National Academy of Sciences of the United States of America
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Broad spectrum antiviral remdesivir inhibits human endemic and zoonotic deltacoronaviruses with a highly divergent RNA dependent RNA polymerase
π€ Brown, Ariane J. π€ Won, John J. π€ Graham, Rachel L. π€ Dinnon, Kenneth H. π€ Sims, Amy C. π€ Feng, Joy Y. π€ Cihlar, Tomas π€ Denison, Mark R. π€ Baric, Ralph S. π€ Sheahan, Timothy P. β° 2019 π Antiviral Research
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Reverse genetic analysis of the transcription regulatory sequence of the coronavirus transmissible gastroenteritis virus
π€ Curtis, Kristopher M. π€ Yount, Boyd π€ Sims, Amy C. π€ Baric, Ralph S. β° 2004 π Journal of Virology
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Systematic assembly of a full-length infectious clone of human coronavirus NL63
π€ Donaldson, Eric F. π€ Yount, Boyd π€ Sims, Amy C. π€ Burkett, Susan π€ Pickles, Raymond J. π€ Baric, Ralph S. β° 2008 π Journal of Virology
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The nsp2 replicase proteins of murine hepatitis virus and severe acute respiratory syndrome coronavirus are dispensable for viral replication
π€ Graham, Rachel L. π€ Sims, Amy C. π€ Brockway, Sarah M. π€ Baric, Ralph S. π€ Denison, Mark R. β° 2005 π Journal of Virology
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SARS coronavirus replicase proteins in pathogenesis
π€ Graham, Rachel L. π€ Sparks, Jennifer S. π€ Eckerle, Lance D. π€ Sims, Amy C. π€ Denison, Mark R. β° 2008 π Virus Research
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Human coronavirus HKU1 spike protein uses O-acetylated sialic acid as an attachment receptor determinant and employs hemagglutinin-esterase protein as a receptor-destroying enzyme
π€ Huang, Xingchuan π€ Dong, Wenjuan π€ Milewska, Aleksandra π€ Golda, Anna π€ Qi, Yonghe π€ Zhu, Quan K. π€ Marasco, Wayne A. π€ Baric, Ralph S. π€ Sims, Amy C. π€ Pyrc, Krzysztof π€ Li, Wenhui π€ Sui, Jianhua β° 2015 π Journal of Virology
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RNA dimerization plays a role in ribosomal frameshifting of the SARS coronavirus
π€ Ishimaru, Daniella π€ Plant, Ewan P. π€ Sims, Amy C. π€ Yount Jr., Boyd L. π€ Roth, Braden M. π€ Eldho, Nadukkudy V. π€ PΓ©rez-Alvarado, Gabriela C. π€ Armbruster, David W. π€ Baric, Ralph S. π€ Dinman, Jonathan D. π€ Taylor, Deborah R. π€ Hennig, Mirko β° 2013 π Nucleic Acids Research
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Pathogenic influenza viruses and coronaviruses utilize similar and contrasting approaches to control interferon-stimulated gene responses
π€ Menachery, Vineet D. π€ Eisfeld, Amie J. π€ SchΓ€fer, Alexandra π€ Josset, Laurence π€ Sims, Amy C. π€ Proll, Sean π€ Fan, Shufang π€ Li, Chengjun π€ Neumann, Gabriele π€ Tilton, Susan C. π€ Chang, Jean π€ Gralinski, Lisa E. π€ Long, Casey π€ Green, Richard π€ Williams, Christopher M. π€ Weiss, Jeffrey π€ Matzke, Melissa M. π€ Webb-Robertson, Bobbie Jo π€ Schepmoes, Athena A. π€ Shukla, Anil K. π€ Metz, Thomas O. π€ Smith, Richard D. π€ Waters, Katrina M. π€ Katze, Michael G. π€ Kawaoka, Yoshihiro π€ Baric, Ralph S. β° 2014 π mBio
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Middle East respiratory syndrome coronavirus nonstructural protein 16 is necessary for interferon resistance and viral pathogenesis
π€ Menachery, Vineet D. π€ Gralinski, Lisa E. π€ Mitchell, Hugh D. π€ Dinnon, Kenneth H. π€ Leist, Sarah R. π€ Yount, Boyd L. π€ Graham, Rachel L. π€ McAnarney, Eileen T. π€ Stratton, Kelly G. π€ Cockrell, Adam S. π€ Debbink, Kari π€ Sims, Amy C. π€ Waters, Katrina M. π€ Baric, Ralph S. β° 2017 π mSphere
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Altering SARS coronavirus frameshift efficiency affects genomic and subgenomic RNA production
π€ Plant, Ewan P. π€ Sims, Amy C. π€ Baric, Ralph S. π€ Dinman, Jonathan D. π€ Taylor, Deborah R. β° 2013 π Viruses
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Culturing the unculturable: Human coronavirus HKU1 infects, replicates, and produces progeny virions in human ciliated airway epithelial cell cultures
π€ Pyrc, Krzysztof π€ Sims, Amy C. π€ Dijkman, Ronald π€ Jebbink, Maarten π€ Long, Casey π€ Deming, Damon π€ Donaldson, Eric π€ Vabret, Astrid π€ Baric, Ralph π€ Van Der Hoek, Lia π€ Pickles, Raymond β° 2010 π Journal of Virology
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Reverse genetics with a full-length infectious cDNA of the Middle East respiratory syndrome coronavirus
π€ Scobey, Trevor π€ Yount, Boyd L. π€ Sims, Amy C. π€ Donaldson, Eric F. π€ Agnihothram, Sudhakar S. π€ Menachery, Vineet D. π€ Graham, Rachel L. π€ Swanstrom, Jesica π€ Bove, Peter F. π€ Kim, Jeeho D. π€ Grego, Sonia π€ Randell, Scott H. π€ Baric, Ralph S. β° 2013 π Proceedings of the National Academy of Sciences of the United States of America
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An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 in human airway epithelial cell cultures and multiple coronaviruses in mice.
π€ Sheahan, Timothy P π€ Sims, Amy C π€ Zhou, Shuntai π€ Graham, Rachel L π€ Pruijssers, Andrea J π€ Agostini, Maria L π€ Leist, Sarah R π€ Schafer, Alexandra π€ Dinnon, Kenneth H 3rd π€ Stevens, Laura J π€ Chappell, James D π€ Lu, Xiaotao π€ Hughes, Tia M π€ George, Amelia S π€ Hill, Collin S π€ Montgomery, Stephanie A π€ Brown, Ariane J π€ Bluemling, Gregory R π€ Natchus, Michael G π€ Saindane, Manohar π€ Kolykhalov, Alexander A π€ Painter, George π€ Harcourt, Jennifer π€ Tamin, Azaibi π€ Thornburg, Natalie J π€ Swanstrom, Ronald π€ Denison, Mark R π€ Baric, Ralph S β° 2020 π Sci Transl Med
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Severe acute respiratory syndrome coronavirus infection of human ciliated airway epithelia: Role of ciliated cells in viral spread in the conducting airways of the lungs
π€ Sims, Amy C. π€ Baric, Ralph S. π€ Yount, Boyd π€ Burkett, Susan E. π€ Collins, Peter L. π€ Pickles, Raymond J. β° 2005 π Journal of Virology
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Release of severe acute respiratory syndrome coronavirus nuclear import block enhances host transcription in human lung cells
π€ Sims, Amy C. π€ Tilton, Susan C. π€ Menachery, Vineet D. π€ Gralinski, Lisa E. π€ SchΓ€fer, Alexandra π€ Matzke, Melissa M. π€ Webb-Robertson, Bobbie Jo M. π€ Chang, Jean π€ Luna, Maria L. π€ Long, Casey E. π€ Shukla, Anil K. π€ Bankhead III, Armand R. π€ Burkett, Susan E. π€ Zornetzer, Gregory π€ Tseng, Chien Te Kent π€ Metz, Thomas O. π€ Pickles, Raymond π€ McWeeney, Shannon π€ Smith, Richard D. π€ Katze, Michael G. π€ Waters, Katrina M. π€ Barica, Ralph S. β° 2013 π Journal of Virology
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Zn2+ inhibits coronavirus and arterivirus RNA polymerase activity in vitro and zinc ionophores block the replication of these viruses in cell culture
π€ te Velthuis, Aartjan J.W. π€ van den Worml, Sjoerd H.E. π€ Sims, Amy C. π€ Baric, Ralph S. π€ Snijder, Eric J. π€ van Hemert, Martijn J. β° 2010 π PLoS Pathogens
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Severe acute respiratory syndrome coronavirus group-specific open reading frames encode nonessential functions for replication in cell cultures and mice
π€ Yount, Boyd π€ Roberts, Rhonda S. π€ Sims, Amy C. π€ Deming, Damon π€ Frieman, Matthew B. π€ Sparks, Jennifer π€ Denison, Mark R. π€ Davis, Nancy π€ Baric, Ralph S. β° 2005 π Journal of Virology