π€ Denison, Mark R.
Keywords
Articles (37)
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Evaluation of serologic and antigenic relationships between middle eastern respiratory syndrome coronavirus and other coronaviruses to develop vaccine platforms for the rapid response to emerging coronaviruses
π€ Agnihothram, Sudhakar π€ Gopal, Robin π€ Yount, Boyd L. π€ Donaldson, Eric F. π€ Menachery, Vineet D. π€ Graham, Rachel L. π€ Scobey, Trevor D. π€ Gralinski, Lisa E. π€ Denison, Mark R. π€ Zambon, Maria π€ Baric, Ralph S. β° 2014 π Journal of Infectious Diseases
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A mouse model for Betacoronavirus subgroup 2c using a bat coronavirus strain HKU5 variant
π€ Agnihothram, Sudhakar π€ Yount Jr., Boyd L. π€ Donaldson, Eric F. π€ Huynh, Jeremy π€ Menachery, Vineet D. π€ Gralinski, Lisa E. π€ Graham, Rachel L. π€ Becker, Michelle M. π€ Tomar, Sakshi π€ Scobey, Trevor D. π€ Osswald, Heather L. π€ Whitmore, Alan π€ Gopal, Robin π€ Ghosh, Arun K. π€ Mesecar, Andrew π€ Zambon, Maria π€ Heise, Mark π€ Denison, Mark R. π€ Baric, Ralph S. β° 2014 π mBio
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Coronavirus susceptibility to the antiviral remdesivir (GS-5734) is mediated by the viral polymerase and the proofreading exoribonuclease
π€ Agostini, Maria L. π€ Andres, Erica L. π€ Sims, Amy C. π€ Graham, Rachel L. π€ Sheahan, Timothy P. π€ Lu, Xiaotao π€ Smith, Everett Clinton π€ Case, James Brett π€ Feng, Joy Y. π€ Jordan, Robert π€ Ray, Adrian S. π€ Cihlar, Tomas π€ Siegel, Dustin π€ Mackman, Richard L. π€ Clarke, Michael O. π€ Baric, Ralph S. π€ Denison, Mark R. β° 2018 π mBio
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Small-Molecule Antiviral Ξ²-d-N4-Hydroxycytidine Inhibits a Proofreading-Intact Coronavirus with a High Genetic Barrier to Resistance
π€ Agostini, Maria L. π€ Pruijssers, Andrea J. π€ Chappell, James D. π€ Gribble, Jennifer π€ Lu, Xiaotao π€ Andres, Erica L. π€ Bluemling, Gregory R. π€ Lockwood, Mark A. π€ Sheahan, Timothy P. π€ Sims, Amy C. π€ Natchus, Michael G. π€ Saindane, Manohar π€ Kolykhalov, Alexander A. π€ Painter, George R. π€ Baric, Ralph S. π€ Denison, Mark R. β° 2019 π Journal of virology
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In situ tagged nsp15 reveals interactions with coronavirus replication/transcription complex associated proteins
π€ Athmer, Jeremiah π€ Fehr, Anthony R. π€ Grunewald, Matthew π€ Smith, Everett Clinton π€ Denison, Mark R. π€ Perlman, Stanley β° 2017 π mBio
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Selective packaging in murine coronavirus promotes virulence by limiting type I interferon responses
π€ Athmer, Jeremiah π€ Fehr, Anthony R. π€ Grunewald, Matthew E. π€ Qu, Wen π€ Wheeler, D. Lori π€ Graepel, Kevin W. π€ Channappanavar, Rudragouda π€ Sekine, Aimee π€ Aldabeeb, Dana Saud π€ Gale, Michael π€ Denison, Mark R. π€ Perlman, Stanley β° 2018 π mBio
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Synthetic recombinant bat SARS-like coronavirus is infectious in cultured cells and in mice
π€ Becker, Michelle M. π€ Graham, Rachel L. π€ Donaldson, Eric F. π€ Rockx, Barry π€ Sims, Amy C. π€ Sheahan, Timothy π€ Pickles, Raymond J. π€ Corti, Davide π€ Johnston, Robert E. π€ Baric, Ralph S. π€ Denison, Mark R. β° 2008 π Proceedings of the National Academy of Sciences of the United States of America
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Molecular targets for the rational design of drugs to inhibit SARS coronavirus
π€ Brockway, Sarah M. π€ Denison, Mark R. β° 2004 π Drug Discovery Today: Disease Mechanisms
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Broad spectrum antiviral remdesivir inhibits human endemic and zoonotic deltacoronaviruses with a highly divergent RNA dependent RNA polymerase
π€ Brown, Ariane J. π€ Won, John J. π€ Graham, Rachel L. π€ Dinnon, Kenneth H. π€ Sims, Amy C. π€ Feng, Joy Y. π€ Cihlar, Tomas π€ Denison, Mark R. π€ Baric, Ralph S. π€ Sheahan, Timothy P. β° 2019 π Antiviral Research
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Severe acute respiratory syndrome coronavirus pathogenesis, disease and vaccines: An update
π€ Denison, Mark R. β° 2004 π Pediatric Infectious Disease Journal
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Coronaviruses: An RNA proofreading machine regulates replication fidelity and diversity
π€ Denison, Mark R. π€ Graham, Rachel L. π€ Donaldson, Eric F. π€ Eckerle, Lance D. π€ Baric, Ralph S. β° 2011 π RNA Biology
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Identification and characterization of a 65-kDa protein processed from the gene 1 polyprotein of the murine coronavirus MHV-A59
π€ Denison, Mark R. π€ Hughes, Scott A. π€ Weiss, Susan R. β° 1995 π Virology
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Intracellular processing of the N-terminal ORF 1a proteins of the coronavirus MHV-A59 requires multiple proteolytic events
π€ Denison, Mark R. π€ Zoltick, Philip W. π€ Hughes, Scott A. π€ Giangreco, Bernadette π€ Olson, Ann L. π€ Perlman, Stanley π€ Leibowitz, Julian L. π€ Weiss, Susan R. β° 1992 π Virology
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Coronavirus replicase-reporter fusions provide quantitative analysis of replication and replication complex formation
π€ Freeman, Megan Culler π€ Graham, Rachel L. π€ Lu, Xiaotao π€ Peek, Christopher T. π€ Denison, Mark R. β° 2014 π Journal of Virology
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Coronaviruses induce entry-independent, Continuous macropinocytosis
π€ Freeman, Megan Culler π€ Peek, Christopher T. π€ Becker, Michelle M. π€ Smith, Everett Clinton π€ Denison, Mark R. β° 2014 π mBio
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Exchange of the coronavirus replicase polyprotein cleavage sites alters protease specificity and processing
π€ Gadlage, Mark J. π€ Denison, Mark R. β° 2010 π Journal of Virology
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Murine coronaviruses encoding nsp2 at different genomic loci have altered replication, protein expression, and localization
π€ Gadlage, Mark J. π€ Graham, Rachel L. π€ Denison, Mark R. β° 2008 π Journal of Virology
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A live, impaired-fidelity coronavirus vaccine protects in an aged, immunocompromised mouse model of lethal disease
π€ Graham, Rachel L. π€ Becker, Michelle M. π€ Eckerle, Lance D. π€ Bolles, Meagan π€ Denison, Mark R. π€ Baric, Ralph S. β° 2012 π Nature Medicine
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The nsp2 replicase proteins of murine hepatitis virus and severe acute respiratory syndrome coronavirus are dispensable for viral replication
π€ Graham, Rachel L. π€ Sims, Amy C. π€ Brockway, Sarah M. π€ Baric, Ralph S. π€ Denison, Mark R. β° 2005 π Journal of Virology
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SARS coronavirus replicase proteins in pathogenesis
π€ Graham, Rachel L. π€ Sparks, Jennifer S. π€ Eckerle, Lance D. π€ Sims, Amy C. π€ Denison, Mark R. β° 2008 π Virus Research
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Distinct patterns of IFITM-mediated restriction of filoviruses, SARS coronavirus, and influenza A virus
π€ Huang, I. Chueh π€ Bailey, Charles C. π€ Weyer, Jessica L. π€ Radoshitzky, Sheli R. π€ Becker, Michelle M. π€ Chiang, Jessica J. π€ Brass, Abraham L. π€ Ahmed, Asim A. π€ Chi, Xiaoli π€ Dong, Lian π€ Longobardi, Lindsay E. π€ Boltz, Dutch π€ Kuhn, Jens H. π€ Elledge, Stephen J. π€ Bavari, Sina π€ Denison, Mark R. π€ Choe, Hyeryun π€ Farzan, Michael β° 2011 π PLoS Pathogens
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Coronavirus protein processing and RNA synthesis is inhibited by the cysteine proteinase inhibitor E64d
π€ Kim, James C. π€ Spence, Robert A. π€ Currier, Paul F. π€ Lu, Xiaotao π€ Denison, Mark R. β° 1995 π Virology
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Intracellular and in vitro-translated 27-kDa proteins contain the 3C-like proteinase activity of the coronavirus MHV-A59
π€ Lu, Xiaotao π€ Lu, Yiqi π€ Denison, Mark R. β° 1996 π Virology
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Coronavirus Replication Complex Formation Utilizes Components of Cellular Autophagy
π€ Prentice, Erik π€ Jerome, W. Gray π€ Yoshimori, Tamotsu π€ Mizushima, Noboru π€ Denison, Mark R. β° 2004 π Journal of Biological Chemistry
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Identification and characterization of severe acute respiratory syndrome coronavirus replicase proteins
π€ Prentice, Erik π€ McAuliffe, Josephine π€ Lu, Xiaotao π€ Subbarao, Kanta π€ Denison, Mark R. β° 2004 π Journal of Virology
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Nucleoside analogues for the treatment of coronavirus infections
π€ Pruijssers, Andrea J. π€ Denison, Mark R. β° 2019 π Current Opinion in Virology
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Homology-based identification of a mutation in the coronavirus RNA-dependent RNA polymerase that confers resistance to multiple mutagens
π€ Sexton, Nicole R. π€ Smith, Everett Clinton π€ Blanc, HervΓ© π€ Vignuzzi, Marco π€ Peersen, Olve B. π€ Denison, Mark R. β° 2016 π Journal of Virology
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An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 in human airway epithelial cell cultures and multiple coronaviruses in mice.
π€ Sheahan, Timothy P π€ Sims, Amy C π€ Zhou, Shuntai π€ Graham, Rachel L π€ Pruijssers, Andrea J π€ Agostini, Maria L π€ Leist, Sarah R π€ Schafer, Alexandra π€ Dinnon, Kenneth H 3rd π€ Stevens, Laura J π€ Chappell, James D π€ Lu, Xiaotao π€ Hughes, Tia M π€ George, Amelia S π€ Hill, Collin S π€ Montgomery, Stephanie A π€ Brown, Ariane J π€ Bluemling, Gregory R π€ Natchus, Michael G π€ Saindane, Manohar π€ Kolykhalov, Alexander A π€ Painter, George π€ Harcourt, Jennifer π€ Tamin, Azaibi π€ Thornburg, Natalie J π€ Swanstrom, Ronald π€ Denison, Mark R π€ Baric, Ralph S β° 2020 π Sci Transl Med
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Implications of altered replication fidelity on the evolution and pathogenesis of coronaviruses
π€ Smith, Everett C. π€ Denison, Mark R. β° 2012 π Current Opinion in Virology
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Coronaviruses Lacking Exoribonuclease Activity Are Susceptible to Lethal Mutagenesis: Evidence for Proofreading and Potential Therapeutics
π€ Smith, Everett Clinton π€ Blanc, HervΓ© π€ Vignuzzi, Marco π€ Denison, Mark R. β° 2013 π PLoS Pathogens
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Mutations in coronavirus nonstructural protein 10 decrease virus replication fidelity
π€ Smith, Everett Clinton π€ Case, James Brett π€ Blanc, HervΓ© π€ Isakov, Ofer π€ Shomron, Noam π€ Vignuzzi, Marco π€ Denison, Mark R. β° 2015 π Journal of Virology
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Single-amino-acid substitutions in open reading frame (ORF) 1b-nsp14 and ORF 2a proteins of the coronavirus mouse hepatitis virus are attenuating in mice
π€ Sperry, Steven M. π€ Kazi, Lubna π€ Graham, Rachel L. π€ Baric, Ralph S. π€ Weiss, Susan R. π€ Denison, Mark R. β° 2005 π Journal of Virology
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Chimeric exchange of coronavirus nsp5 proteases (3CLpro) identifies common and divergent regulatory determinants of protease activity
π€ Stobart, Christopher C. π€ Sexton, Nicole R. π€ Munjal, Havisha π€ Lu, Xiaotao π€ Molland, Katrina L. π€ Tomar, Sakshi π€ Mesecar, Andrew D. π€ Denison, Mark R. β° 2013 π Journal of Virology
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Ligand-induced dimerization of Middle East Respiratory Syndrome (MERS) Coronavirus nsp5 protease (3CLpro): Implications for nsp5 regulation and the development of antivirals
π€ Tomar, Sakshi π€ Johnston, Melanie L. π€ John, Sarah E.St π€ Osswald, Heather L. π€ Nyalapatla, Prasanth R. π€ Paul, Lake N. π€ Ghosh, Arun K. π€ Denison, Mark R. π€ Mesecar, Andrew D. β° 2015 π Journal of Biological Chemistry
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Reverse genetics with a full-length infectious cDNA of severe acute respiratory syndrome coronavirus
π€ Yount, Boyd π€ Curtis, Kristopher M. π€ Fritz, Elizabeth A. π€ Hensley, Lisa E. π€ Jahrling, Peter B. π€ Prentice, Erik π€ Denison, Mark R. π€ Geisbert, Thomas W. π€ Baric, Ralph S. β° 2003 π Proceedings of the National Academy of Sciences of the United States of America
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Severe acute respiratory syndrome coronavirus group-specific open reading frames encode nonessential functions for replication in cell cultures and mice
π€ Yount, Boyd π€ Roberts, Rhonda S. π€ Sims, Amy C. π€ Deming, Damon π€ Frieman, Matthew B. π€ Sparks, Jennifer π€ Denison, Mark R. π€ Davis, Nancy π€ Baric, Ralph S. β° 2005 π Journal of Virology
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Coronavirus replication does not require the autophagy gene ATG5
π€ Zhao, Zijiang π€ Thackray, Larissa B. π€ Miller, Brian C. π€ Lynn, Teresa M. π€ Becker, Michelle M. π€ Ward, Eric π€ Mizushima, Noboru N. π€ Denison, Mark R. π€ Virgin IV, Herbert W. β° 2007 π Autophagy