ghosh-arun-k

Keywords

🔗 severe acute (1373) 🔗 reading frame (222) 🔗 weight loss (41) 🔗 amino acid (454) 🔗 respiratory syndrome (2004) 🔗 acute respiratory (1734) 🔗 cell culture (240) 🔗 epithelial cells (128) 🔗 open reading (215) 🔗 diffuse alveolar (21) 🔗 enzymatic activity (29) 🔗 papain-like protease (67) 🔗 innate immune (105) 🔗 human coronavirus (623) 🔗 immune response (314) 🔗 results indicate (178) 🔗 viral replication (258) 🔗 reverse genetics (49) 🔗 causative agent (117) 🔗 hepatitis virus (437) 🔗 mouse hepatitis (371) 🔗 infectious virus (88) 🔗 drug design (36) 🔗 crystal structure (114) 🔗 syndrome coronavirus (1074) 🔗 plasmon resonance (20) 🔗 virus replication (219) 🔗 amino acids (205)

Articles (7)

A mouse model for Betacoronavirus subgroup 2c using a bat coronavirus strain HKU5 variant
👤 Agnihothram, Sudhakar 👤 Yount Jr., Boyd L. 👤 Donaldson, Eric F. 👤 Huynh, Jeremy 👤 Menachery, Vineet D. 👤 Gralinski, Lisa E. 👤 Graham, Rachel L. 👤 Becker, Michelle M. 👤 Tomar, Sakshi 👤 Scobey, Trevor D. 👤 Osswald, Heather L. 👤 Whitmore, Alan 👤 Gopal, Robin 👤 Ghosh, Arun K. 👤 Mesecar, Andrew 👤 Zambon, Maria 👤 Heise, Mark 👤 Denison, Mark R. 👤 Baric, Ralph S. ⏰ 2014 📚 mBio
Deubiquitinating and interferon antagonism activities of coronavirus papain-like proteases
👤 Clementz, Mark A. 👤 Chen, Zhongbin 👤 Banach, Bridget S. 👤 Wang, Yanhua 👤 Sun, Li 👤 Ratia, Kiira 👤 Baez-Santos, Yahira M. 👤 Wang, Jie 👤 Takayama, Jun 👤 Ghosh, Arun K. 👤 Li, Kui 👤 Mesecar, Andrew D. 👤 Baker, Susan C. ⏰ 2010 📚 Journal of Virology
Coronaviruses resistant to a 3C-like protease inhibitor are attenuated for replication and pathogenesis, revealing a low genetic barrier but high fitness cost of resistance
👤 Deng, Xufang 👤 St John, Sarah E. 👤 Osswald, Heather L. 👤 O'Brien, Amornrat 👤 Banach, Bridget S. 👤 Sleeman, Katrina 👤 Ghosh, Arun K. 👤 Mesecar, Andrew D. 👤 Baker, Susan C. ⏰ 2014 📚 Journal of Virology
Structure-based design, synthesis, and biological evaluation of a series of novel and reversible inhibitors for the severe acute respiratory syndrome - Coronavirus papain-like protease
👤 Ghosh, Arun K. 👤 Takayama, Jun 👤 Aubin, Yoann 👤 Ratia, Kiira 👤 Chaudhuri, Rima 👤 Baez, Yahira 👤 Sleeman, Katrina 👤 Coughlin, Melissa 👤 Nichols, Daniel B. 👤 Mulhearn, Debbie C. 👤 Prabhakar, Bellur S. 👤 Baker, Susan C. 👤 Johnson, Michael E. 👤 Mesecar, Andrew D. ⏰ 2009 📚 Journal of Medicinal Chemistry
Severe acute respiratory syndrome coronavirus papain-like novel protease inhibitors: Design, synthesis, protein-ligand X-ray structure and biological evaluation
👤 Ghosh, Arun K. 👤 Takayama, Jun 👤 Rao, Kalapala Venkateswara 👤 Ratia, Kiira 👤 Chaudhuri, Rima 👤 Mulhearn, Debbie C. 👤 Lee, Hyun 👤 Nichols, Daniel B. 👤 Baliji, Surendranath 👤 Baker, Susan C. 👤 Johnson, Michael E. 👤 Mesecar, Andrew D. ⏰ 2010 📚 Journal of Medicinal Chemistry
Synergistic inhibitor binding to the papain-like protease of human SARS coronavirus: Mechanistic and inhibitor design implications
👤 Lee, Hyun 👤 Cao, Shuyi 👤 Hevener, Kirk E. 👤 Truong, Lena 👤 Gatuz, Joseph L. 👤 Patel, Kavankumar 👤 Ghosh, Arun K. 👤 Johnson, Michael E. ⏰ 2013 📚 ChemMedChem
Ligand-induced dimerization of Middle East Respiratory Syndrome (MERS) Coronavirus nsp5 protease (3CLpro): Implications for nsp5 regulation and the development of antivirals
👤 Tomar, Sakshi 👤 Johnston, Melanie L. 👤 John, Sarah E.St 👤 Osswald, Heather L. 👤 Nyalapatla, Prasanth R. 👤 Paul, Lake N. 👤 Ghosh, Arun K. 👤 Denison, Mark R. 👤 Mesecar, Andrew D. ⏰ 2015 📚 Journal of Biological Chemistry