nichols-daniel-b

Keywords

🔗 severe acute (1373) 🔗 syndrome coronavirus (1074) 🔗 papain-like protease (67) 🔗 infected cells (307) 🔗 respiratory syndrome (2004) 🔗 acute respiratory (1734) 🔗 drug design (36) 🔗 crystal structure (114) 🔗 cells expressing (60) 🔗 endoplasmic reticulum (78) 🔗 innate immune (105) 🔗 human coronavirus (623) 🔗 immune response (314) 🔗 wild type (34)

Articles (4)

A chimeric virus-mouse model system for evaluating the function and inhibition of papain-like proteases of emerging coronaviruses
👤 Deng, Xufang 👤 Agnihothram, Sudhakar 👤 Mielech, Anna M. 👤 Nichols, Daniel B. 👤 Wilson, Michael W. 👤 St. John, Sarah E. 👤 Larsen, Scott D. 👤 Mesecar, Andrew D. 👤 Lenschow, Deborah J. 👤 Baric, Ralph S. 👤 Baker, Susan C. ⏰ 2014 📚 Journal of Virology
Structure-based design, synthesis, and biological evaluation of a series of novel and reversible inhibitors for the severe acute respiratory syndrome - Coronavirus papain-like protease
👤 Ghosh, Arun K. 👤 Takayama, Jun 👤 Aubin, Yoann 👤 Ratia, Kiira 👤 Chaudhuri, Rima 👤 Baez, Yahira 👤 Sleeman, Katrina 👤 Coughlin, Melissa 👤 Nichols, Daniel B. 👤 Mulhearn, Debbie C. 👤 Prabhakar, Bellur S. 👤 Baker, Susan C. 👤 Johnson, Michael E. 👤 Mesecar, Andrew D. ⏰ 2009 📚 Journal of Medicinal Chemistry
Severe acute respiratory syndrome coronavirus papain-like novel protease inhibitors: Design, synthesis, protein-ligand X-ray structure and biological evaluation
👤 Ghosh, Arun K. 👤 Takayama, Jun 👤 Rao, Kalapala Venkateswara 👤 Ratia, Kiira 👤 Chaudhuri, Rima 👤 Mulhearn, Debbie C. 👤 Lee, Hyun 👤 Nichols, Daniel B. 👤 Baliji, Surendranath 👤 Baker, Susan C. 👤 Johnson, Michael E. 👤 Mesecar, Andrew D. ⏰ 2010 📚 Journal of Medicinal Chemistry
Coronavirus papain-like proteases negatively regulate antiviral innate immune response through disruption of STING-mediated signaling
👤 Sun, Li 👤 Xing, Yaling 👤 Chen, Xiaojuan 👤 Zheng, Yang 👤 Yang, Yudong 👤 Nichols, Daniel B. 👤 Clementz, Mark A. 👤 Banach, Bridget S. 👤 Li, Kui 👤 Baker, Susan C. 👤 Chen, Zhongbin ⏰ 2012 📚 PLoS ONE