👤 Baker, Susan C.

Keywords

Articles (38)

• Competitive fitness in coronaviruses is not correlated with size or number of double-membrane vesicles under reduced-temperature growth conditions

  👤 Al-Mulla, Hawaa M.N. 👤 Turrell, Lauren 👤 Smith, Nicola M. 👤 Payne, Luke 👤 Baliji, Surendranath 👤 Züst, Roland 👤 Thiel, Volker 👤 Baker, Susan C. 👤 Siddell, Stuart G. 👤 Neuman, Benjamin W. ⏰ 2014 📚 mBio

• Detection of nonstructural protein 6 in murine coronavirus-infected cells and analysis of the transmembrane topology by using bioinformatics and molecular approaches

  👤 Baliji, Surendranath 👤 Cammer, Stephen A. 👤 Sobral, Bruno 👤 Baker, Susan C. ⏰ 2009 📚 Journal of Virology

• The papain-like protease of severe acute respiratory syndrome coronavirus has deubiquitinating activity

  👤 Barretto, Naina 👤 Jukneliene, Dalia 👤 Ratia, Kiira 👤 Chen, Zhongbin 👤 Mesecar, Andrew D. 👤 Baker, Susan C. ⏰ 2005 📚 Journal of Virology

• Coronavirus infection modulates the unfolded protein response and mediates sustained translational repression

  👤 Bechill, John 👤 Chen, Zhongbin 👤 Brewer, Joseph W. 👤 Baker, Susan C. ⏰ 2008 📚 Journal of Virology

• X-ray structural and biological evaluation of a series of potent and highly selective inhibitors of human coronavirus papain-like proteases

  👤 Báez-Santos, Yahira M. 👤 Barraza, Scott J. 👤 Wilson, Michael W. 👤 Agius, Michael P. 👤 Mielech, Anna M. 👤 Davis, Nicole M. 👤 Baker, Susan C. 👤 Larsen, Scott D. 👤 Mesecar, Andrew D. ⏰ 2014 📚 Journal of Medicinal Chemistry

• Proteolytic processing and deubiquitinating activity of papain-like proteases of human coronavirus NL63

  👤 Chen, Zhongbin 👤 Wang, Yanhua 👤 Ratia, Kiira 👤 Mesecar, Andrew D. 👤 Wilkinson, Keith D. 👤 Baker, Susan C. ⏰ 2007 📚 Journal of Virology

• X-ray structure and enzymatic activity profile of a core papain-like protease of MERS coronavirus with utility for structure-based drug design

  👤 Clasman, Jozlyn R. 👤 Bez-Santos, Yahira M. 👤 Mettelman, Robert C. 👤 O'Brien, Amornrat 👤 Baker, Susan C. 👤 Mesecar, Andrew D. ⏰ 2017 📚 Scientific Reports

• Deubiquitinating and interferon antagonism activities of coronavirus papain-like proteases

  👤 Clementz, Mark A. 👤 Chen, Zhongbin 👤 Banach, Bridget S. 👤 Wang, Yanhua 👤 Sun, Li 👤 Ratia, Kiira 👤 Baez-Santos, Yahira M. 👤 Wang, Jie 👤 Takayama, Jun 👤 Ghosh, Arun K. 👤 Li, Kui 👤 Mesecar, Andrew D. 👤 Baker, Susan C. ⏰ 2010 📚 Journal of Virology

• Mutation in murine coronavirus replication protein nsp4 alters assembly of double membrane vesicles

  👤 Clementz, Mark A. 👤 Kanjanahaluethai, Amornrat 👤 O'Brien, Timothy E. 👤 Baker, Susan C. ⏰ 2008 📚 Virology

• A chimeric virus-mouse model system for evaluating the function and inhibition of papain-like proteases of emerging coronaviruses

  👤 Deng, Xufang 👤 Agnihothram, Sudhakar 👤 Mielech, Anna M. 👤 Nichols, Daniel B. 👤 Wilson, Michael W. 👤 St. John, Sarah E. 👤 Larsen, Scott D. 👤 Mesecar, Andrew D. 👤 Lenschow, Deborah J. 👤 Baric, Ralph S. 👤 Baker, Susan C. ⏰ 2014 📚 Journal of Virology

• An “Old” protein with a new story: Coronavirus endoribonuclease is important for evading host antiviral defenses

  👤 Deng, Xufang 👤 Baker, Susan C. ⏰ 2018 📚 Virology

• Structure-Guided Mutagenesis Alters Deubiquitinating Activity and Attenuates Pathogenesis of a Murine Coronavirus.

  👤 Deng, Xufang 👤 Chen, Yafang 👤 Mielech, Anna M 👤 Hackbart, Matthew 👤 Kesely, Kristina R 👤 Mettelman, Robert C 👤 O'Brien, Amornrat 👤 Chapman, Mackenzie E 👤 Mesecar, Andrew D 👤 Baker, Susan C ⏰ 2020 📚 J Virol

• Coronavirus nonstructural protein 15 mediates evasion of dsRNA sensors and limits apoptosis in macrophages

  👤 Deng, Xufang 👤 Hackbart, Matthew 👤 Mettelman, Robert C. 👤 O'Brien, Amornrat 👤 Mielech, Anna M. 👤 Yi, Guanghui 👤 Kao, C. Cheng 👤 Baker, Susan C. ⏰ 2017 📚 Proceedings of the National Academy of Sciences of the United States of America

• Analysis of coronavirus temperature-sensitive mutants reveals an interplay between the macrodomain and Papain-like protease impacting replication and pathogenesis

  👤 Deng, Xufang 👤 Mettelman, Robert C. 👤 O'Brien, Amornrat 👤 Thompson, John A. 👤 O'Brien, Timothy E. 👤 Baker, Susan C. ⏰ 2019 📚 Journal of Virology

• Coronaviruses resistant to a 3C-like protease inhibitor are attenuated for replication and pathogenesis, revealing a low genetic barrier but high fitness cost of resistance

  👤 Deng, Xufang 👤 St John, Sarah E. 👤 Osswald, Heather L. 👤 O'Brien, Amornrat 👤 Banach, Bridget S. 👤 Sleeman, Katrina 👤 Ghosh, Arun K. 👤 Mesecar, Andrew D. 👤 Baker, Susan C. ⏰ 2014 📚 Journal of Virology

• Coronavirus endoribonuclease activity in porcine epidemic diarrhea virus suppresses type I and type III interferon responses

  👤 Deng, Xufang 👤 Van Geelen, Albert 👤 Buckley, Alexandra C. 👤 O’Brien, Amornrat 👤 Pillatzki, Angela 👤 Lager, Kelly M. 👤 Faaberg, Kay S. 👤 Baker, Susan C. ⏰ 2019 📚 Journal of Virology

• Regulation of IRF-3-dependent innate immunity by the papain-like protease domain of the severe acute respiratory syndrome coronavirus

  👤 Devaraj, Santhana G. 👤 Wang, Nan 👤 Chen, Zhongbin 👤 Chen, Zihong 👤 Tseng, Monica 👤 Barretto, Naina 👤 Lin, Rongtuan 👤 Peters, Clarence J. 👤 Tseng, Chien Te K. 👤 Baker, Susan C. 👤 Li, Kui ⏰ 2007 📚 Journal of Biological Chemistry

• Determinants of the p28 cleavage site recognized by the first papain-like cysteine proteinase of murine coronavirus

  👤 Dong, Shanghong 👤 Baker, Susan C. ⏰ 1994 📚 Virology

• Identification of the polymerase polyprotein products p72 and p65 of the murine coronavirus MHV-JHM

  👤 Gao, Hong Qiang 👤 Schiller, Jennifer J. 👤 Baker, Susan C. ⏰ 1996 📚 Virus Research

• Structure-based design, synthesis, and biological evaluation of a series of novel and reversible inhibitors for the severe acute respiratory syndrome - Coronavirus papain-like protease

  👤 Ghosh, Arun K. 👤 Takayama, Jun 👤 Aubin, Yoann 👤 Ratia, Kiira 👤 Chaudhuri, Rima 👤 Baez, Yahira 👤 Sleeman, Katrina 👤 Coughlin, Melissa 👤 Nichols, Daniel B. 👤 Mulhearn, Debbie C. 👤 Prabhakar, Bellur S. 👤 Baker, Susan C. 👤 Johnson, Michael E. 👤 Mesecar, Andrew D. ⏰ 2009 📚 Journal of Medicinal Chemistry

• Severe acute respiratory syndrome coronavirus papain-like novel protease inhibitors: Design, synthesis, protein-ligand X-ray structure and biological evaluation

  👤 Ghosh, Arun K. 👤 Takayama, Jun 👤 Rao, Kalapala Venkateswara 👤 Ratia, Kiira 👤 Chaudhuri, Rima 👤 Mulhearn, Debbie C. 👤 Lee, Hyun 👤 Nichols, Daniel B. 👤 Baliji, Surendranath 👤 Baker, Susan C. 👤 Johnson, Michael E. 👤 Mesecar, Andrew D. ⏰ 2010 📚 Journal of Medicinal Chemistry

• Evaluating the 3C-like protease activity of SARS-Coronavirus: Recommendations for standardized assays for drug discovery

  👤 Grum-Tokars, Valerie 👤 Ratia, Kiira 👤 Begaye, Adrian 👤 Baker, Susan C. 👤 Mesecar, Andrew D. ⏰ 2008 📚 Virus Research

• Coronavirus endoribonuclease targets viral polyuridine sequences to evade activating host sensors.

  👤 Hackbart, Matthew 👤 Deng, Xufang 👤 Baker, Susan C ⏰ 2020 📚 Proc Natl Acad Sci U S A

• Identification of severe acute respiratory syndrome coronavirus replicase products and characterization of papain-like protease activity

  👤 Harcourt, Brian H. 👤 Jukneliene, Dalia 👤 Kanjanahaluethai, Amornrat 👤 Bechill, John 👤 Severson, Kari M. 👤 Smith, Catherine M. 👤 Rota, Paul A. 👤 Baker, Susan C. ⏰ 2004 📚 Journal of Virology

• Discovery, synthesis, and structure-based optimization of a series of N -(tert -Butyl)-2-(N -arylamido)-2-(pyridin-3-yl) acetamides (ML188) as potent noncovalent small molecule inhibitors of the severe acute respiratory syndrome coronavirus (SARS-CoV) 3CL protease

  👤 Jacobs, Jon 👤 Grum-Tokars, Valerie 👤 Zhou, Ya 👤 Turlington, Mark 👤 Saldanha, S. Adrian 👤 Chase, Peter 👤 Eggler, Aimee 👤 Dawson, Eric S. 👤 Baez-Santos, Yahira M. 👤 Tomar, Sakshi 👤 Mielech, Anna M. 👤 Baker, Susan C. 👤 Lindsley, Craig W. 👤 Hodder, Peter 👤 Mesecar, Andrew 👤 Stauffer, Shaun R. ⏰ 2013 📚 Journal of Medicinal Chemistry

• Membrane topology of murine coronavirus replicase nonstructural protein 3

  👤 Kanjanahaluethai, Amornrat 👤 Chen, Zhongbin 👤 Jukneliene, Dalia 👤 Baker, Susan C. ⏰ 2007 📚 Virology

• Identification of the murine coronavirus MP1 cleavage site recognized by papain-like proteinase 2

  👤 Kanjanahaluethai, Amornrat 👤 Jukneliene, Dalia 👤 Baker, Susan C. ⏰ 2003 📚 Journal of Virology

• Cell-based antiviral screening against coronaviruses: Developing virus-specific and broad-spectrum inhibitors

  👤 Kilianski, Andy 👤 Baker, Susan C. ⏰ 2014 📚 Antiviral Research

• Assessing activity and inhibition of middle east respiratory syndrome coronavirus papain-like and 3C-like proteases using luciferase-based biosensors

  👤 Kilianski, Andy 👤 Mielech, Anna M. 👤 Deng, Xufang 👤 Baker, Susan C. ⏰ 2013 📚 Journal of Virology

• Primary structure and translation of a defective interfering rna of murine coronavirus

  👤 Makino, Shinji 👤 Shieh, Chien Kou 👤 Soe, Lisa H. 👤 Baker, Susan C. 👤 Lai, Michael M.C. ⏰ 1988 📚 Virology

• Murine coronavirus ubiquitin-like domain is important for papain-like protease stability and viral pathogenesis

  👤 Mielech, Anna M. 👤 Deng, Xufang 👤 Chen, Yafang 👤 Kindler, Eveline 👤 Wheeler, Dorthea L. 👤 Mesecar, Andrew D. 👤 Thiel, Volker 👤 Perlman, Stanley 👤 Baker, Susan C. ⏰ 2015 📚 Journal of Virology

• The papain-like protease determines a virulence trait that varies among members of the SARS-coronavirus species

  👤 Niemeyer, Daniela 👤 Mösbauer, Kirstin 👤 Klein, Eva M. 👤 Sieberg, Andrea 👤 Mettelman, Robert C. 👤 Mielech, Anna M. 👤 Dijkman, Ronald 👤 Baker, Susan C. 👤 Drosten, Christian 👤 Müller, Marcel A. ⏰ 2018 📚 PLoS Pathogens

• Severe acute respiratory syndrome coronavirus papain-like-protease: Structure of a viral deubiquitinating enzyme

  👤 Ratia, Kiira 👤 Saikatendu, Kumar Singh 👤 Santarsiero, Bernard D. 👤 Barreto, Naina 👤 Baker, Susan C. 👤 Stevens, Raymond C. 👤 Mesecar, Andrew D. ⏰ 2006 📚 Proceedings of the National Academy of Sciences of the United States of America

• Human airway epithelial cell culture to identify new respiratory viruses: Coronavirus NL63 as a model

  👤 S. Banach, Bridget 👤 Orenstein, Jan M. 👤 Fox, Linda M. 👤 Randell, Scott H. 👤 Rowley, Anne H. 👤 Baker, Susan C. ⏰ 2009 📚 Journal of Virological Methods

• Processing of the coronavirus MHV-JHM polymerase polyprotein: Identification of precursors and proteolytic products spanning 400 kilodaltons of ORF1a

  👤 Schiller, Jennifer J. 👤 Kanjanahaluethai, Amornrat 👤 Baker, Susan C. ⏰ 1998 📚 Virology

• Human coronavirus NL63 is not detected in the respiratory tracts of children with acute Kawasaki disease

  👤 Shimizu, Chisato 👤 Shike, Hiroko 👤 Baker, Susan C. 👤 Garcia, Francesca 👤 Van Der Hoek, Lia 👤 Kuijpers, Taco W. 👤 Reed, Sharon L. 👤 Rowley, Anne H. 👤 Shulman, Stanford T. 👤 Talbot, Helen K.B. 👤 Williams, John V. 👤 Burns, Jane C. ⏰ 2005 📚 Journal of Infectious Diseases

• Coronavirus papain-like proteases negatively regulate antiviral innate immune response through disruption of STING-mediated signaling

  👤 Sun, Li 👤 Xing, Yaling 👤 Chen, Xiaojuan 👤 Zheng, Yang 👤 Yang, Yudong 👤 Nichols, Daniel B. 👤 Clementz, Mark A. 👤 Banach, Bridget S. 👤 Li, Kui 👤 Baker, Susan C. 👤 Chen, Zhongbin ⏰ 2012 📚 PLoS ONE

• Coronavirus Endoribonuclease and Deubiquitinating Interferon Antagonists Differentially Modulate the Host Response during Replication in Macrophages.

  👤 Volk, Aaron 👤 Hackbart, Matthew 👤 Deng, Xufang 👤 Cruz-Pulido, Yazmin 👤 O'Brien, Amornrat 👤 Baker, Susan C ⏰ 2020 📚 J Virol