mielech-anna-m

Keywords

🔗 papain-like protease (67) 🔗 cell lines (125) 🔗 human coronavirus (623) 🔗 cell line (211) 🔗 crystal structure (114) 🔗 severe acute (1373) 🔗 syndrome coronavirus (1074) 🔗 closely related (222) 🔗 significant differences (40) 🔗 respiratory syndrome (2004) 🔗 acute respiratory (1734) 🔗 infected cells (307) 🔗 amino acid (454) 🔗 innate immune (105) 🔗 statistically significant (37) 🔗 immune response (314) 🔗 murine coronavirus (140) 🔗 viral replication (258) 🔗 bone marrow (31) 🔗 main protease (44) 🔗 acid sequence (108) 🔗 high mortality (78) 🔗 cleavage site (85) 🔗 enzymatic activity (29) 🔗 reverse genetics (49) 🔗 hepatitis virus (437) 🔗 mouse hepatitis (371) 🔗 protective immunity (36) 🔗 epithelial cells (128)

Articles (9)

X-ray structural and biological evaluation of a series of potent and highly selective inhibitors of human coronavirus papain-like proteases
👤 Báez-Santos, Yahira M. 👤 Barraza, Scott J. 👤 Wilson, Michael W. 👤 Agius, Michael P. 👤 Mielech, Anna M. 👤 Davis, Nicole M. 👤 Baker, Susan C. 👤 Larsen, Scott D. 👤 Mesecar, Andrew D. ⏰ 2014 📚 Journal of Medicinal Chemistry
Catalytic function and substrate specificity of the papain-like protease domain of nsp3 from the middle east respiratory syndrome coronavirus
👤 Báez-Santos, Yahira M. 👤 Mielech, Anna M. 👤 Deng, Xufang 👤 Baker, Susan 👤 Mesecar, Andrew D. ⏰ 2014 📚 Journal of Virology
A chimeric virus-mouse model system for evaluating the function and inhibition of papain-like proteases of emerging coronaviruses
👤 Deng, Xufang 👤 Agnihothram, Sudhakar 👤 Mielech, Anna M. 👤 Nichols, Daniel B. 👤 Wilson, Michael W. 👤 St. John, Sarah E. 👤 Larsen, Scott D. 👤 Mesecar, Andrew D. 👤 Lenschow, Deborah J. 👤 Baric, Ralph S. 👤 Baker, Susan C. ⏰ 2014 📚 Journal of Virology
Structure-Guided Mutagenesis Alters Deubiquitinating Activity and Attenuates Pathogenesis of a Murine Coronavirus.
👤 Deng, Xufang 👤 Chen, Yafang 👤 Mielech, Anna M 👤 Hackbart, Matthew 👤 Kesely, Kristina R 👤 Mettelman, Robert C 👤 O'Brien, Amornrat 👤 Chapman, Mackenzie E 👤 Mesecar, Andrew D 👤 Baker, Susan C ⏰ 2020 📚 J Virol
Coronavirus nonstructural protein 15 mediates evasion of dsRNA sensors and limits apoptosis in macrophages
👤 Deng, Xufang 👤 Hackbart, Matthew 👤 Mettelman, Robert C. 👤 O'Brien, Amornrat 👤 Mielech, Anna M. 👤 Yi, Guanghui 👤 Kao, C. Cheng 👤 Baker, Susan C. ⏰ 2017 📚 Proceedings of the National Academy of Sciences of the United States of America
Discovery, synthesis, and structure-based optimization of a series of N -(tert -Butyl)-2-(N -arylamido)-2-(pyridin-3-yl) acetamides (ML188) as potent noncovalent small molecule inhibitors of the severe acute respiratory syndrome coronavirus (SARS-CoV) 3CL protease
👤 Jacobs, Jon 👤 Grum-Tokars, Valerie 👤 Zhou, Ya 👤 Turlington, Mark 👤 Saldanha, S. Adrian 👤 Chase, Peter 👤 Eggler, Aimee 👤 Dawson, Eric S. 👤 Baez-Santos, Yahira M. 👤 Tomar, Sakshi 👤 Mielech, Anna M. 👤 Baker, Susan C. 👤 Lindsley, Craig W. 👤 Hodder, Peter 👤 Mesecar, Andrew 👤 Stauffer, Shaun R. ⏰ 2013 📚 Journal of Medicinal Chemistry
Assessing activity and inhibition of middle east respiratory syndrome coronavirus papain-like and 3C-like proteases using luciferase-based biosensors
👤 Kilianski, Andy 👤 Mielech, Anna M. 👤 Deng, Xufang 👤 Baker, Susan C. ⏰ 2013 📚 Journal of Virology
Murine coronavirus ubiquitin-like domain is important for papain-like protease stability and viral pathogenesis
👤 Mielech, Anna M. 👤 Deng, Xufang 👤 Chen, Yafang 👤 Kindler, Eveline 👤 Wheeler, Dorthea L. 👤 Mesecar, Andrew D. 👤 Thiel, Volker 👤 Perlman, Stanley 👤 Baker, Susan C. ⏰ 2015 📚 Journal of Virology
The papain-like protease determines a virulence trait that varies among members of the SARS-coronavirus species
👤 Niemeyer, Daniela 👤 Mösbauer, Kirstin 👤 Klein, Eva M. 👤 Sieberg, Andrea 👤 Mettelman, Robert C. 👤 Mielech, Anna M. 👤 Dijkman, Ronald 👤 Baker, Susan C. 👤 Drosten, Christian 👤 Müller, Marcel A. ⏰ 2018 📚 PLoS Pathogens