๐ Enzymatic activity
Articles (29)
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In situ tagged nsp15 reveals interactions with coronavirus replication/transcription complex associated proteins
๐ค Athmer, Jeremiah ๐ค Fehr, Anthony R. ๐ค Grunewald, Matthew ๐ค Smith, Everett Clinton ๐ค Denison, Mark R. ๐ค Perlman, Stanley โฐ 2017 ๐ mBio
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Turkey coronavirus non-structure protein nsp15 - An endoribonuclease
๐ค Cao, Jianzhong ๐ค Wu, Ching Ching ๐ค Lin, Tsang Long โฐ 2009 ๐ Intervirology
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Reversible unfolding of the severe acute respiratory syndrome coronavirus main protease in guanidinium chloride
๐ค Chang, Hui Ping ๐ค Chou, Chi Yuan ๐ค Chang, Gu Gang โฐ 2007 ๐ Biophysical Journal
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Enzymatic activity characterization of SARS coronavirus 3C-like protease by fluorescence resonance energy transfer technique
๐ค Chen, Shuai ๐ค Chen, Li Li ๐ค Luo, Hai Bin ๐ค Sun, Tao ๐ค Chen, Jing ๐ค Ye, Fei ๐ค Cai, Jian Hua ๐ค Shen, Jing Kang ๐ค Shen, Xu ๐ค Jiang, Hua Liang โฐ 2005 ๐ Acta Pharmacologica Sinica
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Severe acute respiratory syndrome coronavirus 3C-like proteinase N terminus is indispensable for proteolytic activity but not for enzyme dimerization: Biochemical and thermodynamic investigation in conjunction with molecular dynamics simulations
๐ค Chen, Shuai ๐ค Chen, Lili ๐ค Tan, Jinzhi ๐ค Chen, Jing ๐ค Du, Li ๐ค Sun, Tao ๐ค Shen, Jianhua ๐ค Chen, Kaixian ๐ค Jiang, Hualiang ๐ค Shen, Xu โฐ 2005 ๐ Journal of Biological Chemistry
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Mutation of Gly-11 on the dimer interface results in the complete crystallographic dimer dissociation of severe acute respiratory syndrome coronavirus 3C-like protease: Crystal structure with molecular dynamics simulations
๐ค Chen, Shuai ๐ค Hu, Tiancen ๐ค Zhang, Jian ๐ค Chen, Jing ๐ค Chen, Kaixian ๐ค Ding, Jianping ๐ค Jiang, Hualiang ๐ค Shen, Xu โฐ 2008 ๐ Journal of Biological Chemistry
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Differential domain structure stability of the severe acute respiratory syndrome coronavirus papain-like protease
๐ค Chou, Ya Wen ๐ค Cheng, Shu Chun ๐ค Lai, Hsing Yi ๐ค Chou, Chi Yuan โฐ 2012 ๐ Archives of Biochemistry and Biophysics
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Design, synthesis and crystallographic analysis of nitrile-based broad-spectrum peptidomimetic inhibitors for coronavirus 3C-like proteases
๐ค Chuck, Chi Pang ๐ค Chen, Chao ๐ค Ke, Zhihai ๐ค Chi-Cheong Wan, David ๐ค Chow, Hak Fun ๐ค Wong, Kam Bo โฐ 2013 ๐ European Journal of Medicinal Chemistry
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Deubiquitinating and interferon antagonism activities of coronavirus papain-like proteases
๐ค Clementz, Mark A. ๐ค Chen, Zhongbin ๐ค Banach, Bridget S. ๐ค Wang, Yanhua ๐ค Sun, Li ๐ค Ratia, Kiira ๐ค Baez-Santos, Yahira M. ๐ค Wang, Jie ๐ค Takayama, Jun ๐ค Ghosh, Arun K. ๐ค Li, Kui ๐ค Mesecar, Andrew D. ๐ค Baker, Susan C. โฐ 2010 ๐ Journal of Virology
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The acetyl-esterase activity of the hemagglutinin-esterase protein of human coronavirus OC43 strongly enhances the production of infectious virus
๐ค Desforges, Marc ๐ค Desjardins, Jessica ๐ค Zhang, Chengsheng ๐ค Talbot, Pierre J. โฐ 2013 ๐ Journal of Virology
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Severe acute respiratory syndrome coronavirus papain-like protease ubiquitin-like domain and catalytic domain regulate antagonism of IRF3 and NF-ฮบB signaling
๐ค Frieman, Matthew ๐ค Ratia, Kiira ๐ค Johnston, Robert E. ๐ค Mesecar, Andrew D. ๐ค Baric, Ralph S. โฐ 2009 ๐ Journal of Virology
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Enzymatic activity of the SARS coronavirus main proteinase dimer
๐ค Graziano, Vito ๐ค McGrath, William J. ๐ค DeGruccio, Ann Marie ๐ค Dunn, John J. ๐ค Mangel, Walter F. โฐ 2006 ๐ FEBS Letters
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Evaluating the 3C-like protease activity of SARS-Coronavirus: Recommendations for standardized assays for drug discovery
๐ค Grum-Tokars, Valerie ๐ค Ratia, Kiira ๐ค Begaye, Adrian ๐ค Baker, Susan C. ๐ค Mesecar, Andrew D. โฐ 2008 ๐ Virus Research
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Papain-like protease 2 (PLP2) from severe acute respiratory syndrome coronavirus (SARS-CoV): Expression, purification, characterization, and inhibition
๐ค Han, Yu San ๐ค Chang, Gu Gang ๐ค Juo, Chiun Gung ๐ค Lee, Hong Jen ๐ค Yen, Shiou Hwei ๐ค Hsu, John Tsu An ๐ค Chen, Xin โฐ 2005 ๐ Biochemistry
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Three dimensional model of severe acute respiratory syndrome coronavirus helicase ATPase catalytic domain and molecular design of severe acute respiratory syndrome coronavirus helicase inhibitors
๐ค Hoffmann, Marcin ๐ค Eitner, Krystian ๐ค Von Grotthuss, Marcin ๐ค Rychlewski, Leszek ๐ค Banachowicz, Ewa ๐ค Grabarkiewicz, Tomasz ๐ค Szkoda, Tomasz ๐ค Kolinski, Andrzej โฐ 2006 ๐ Journal of Computer-Aided Molecular Design
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SARS coronavirus, but not human coronavirus NL63, utilizes cathepsin L to infect ACE2-expressing cells
๐ค Huang, I. Chueh ๐ค Bosch, Berend Jan ๐ค Li, Fang ๐ค Li, Wenhui ๐ค Kyoung, Hoa Lee ๐ค Ghiran, Sorina ๐ค Vasilieva, Natalya ๐ค Dermody, Terence S. ๐ค Harrison, Stephen C. ๐ค Dormitzer, Philip R. ๐ค Farzan, Michael ๐ค Rottier, Peter J.M. ๐ค Choe, Hyeryun โฐ 2006 ๐ Journal of Biological Chemistry
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Characterization of the guanine-N7 methyltransferase activity of coronavirus nsp14 on nucleotide GTP
๐ค Jin, Xu ๐ค Chen, Yu ๐ค Sun, Ying ๐ค Zeng, Cong ๐ค Wang, Yi ๐ค Tao, Jiali ๐ค Wu, Andong ๐ค Yu, Xiao ๐ค Zhang, Zhou ๐ค Tian, Jie ๐ค Guo, Deyin โฐ 2013 ๐ Virus Research
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Crystal structure of a monomeric form of severe acute respiratory syndrome coronavirus endonuclease nsp15 suggests a role for hexamerization as an allosteric switch
๐ค Joseph, Jeremiah S. ๐ค Saikatendu, Kumar Singh ๐ค Subramanian, Vanitha ๐ค Neuman, Benjamin W. ๐ค Buchmeier, Michael J. ๐ค Stevens, Raymond C. ๐ค Kuhn, Peter โฐ 2007 ๐ Journal of Virology
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Mutational and inhibitive analysis of SARS coronavirus 3C-like protease by fluorescence resonance energy transfer-based assays
๐ค Kuang, Wan Fen ๐ค Chow, Lu Ping ๐ค Wu, Mei Hua ๐ค Hwang, Lih Hwa โฐ 2005 ๐ Biochemical and Biophysical Research Communications
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Middle east respiratory syndrome coronavirus spike protein is not activated directly by cellular furin during viral entry into target cells
๐ค Matsuyama, Shutoku ๐ค Shirato, Kazuya ๐ค Kawase, Miyuki ๐ค Terada, Yutaka ๐ค Kawachi, Kengo ๐ค Fukushi, Shuetsu ๐ค Kamitani, Wataru โฐ 2018 ๐ Journal of Virology
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Murine coronavirus ubiquitin-like domain is important for papain-like protease stability and viral pathogenesis
๐ค Mielech, Anna M. ๐ค Deng, Xufang ๐ค Chen, Yafang ๐ค Kindler, Eveline ๐ค Wheeler, Dorthea L. ๐ค Mesecar, Andrew D. ๐ค Thiel, Volker ๐ค Perlman, Stanley ๐ค Baker, Susan C. โฐ 2015 ๐ Journal of Virology
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Retroviruses pseudotyped with the severe acute respiratory syndrome coronavirus spike protein efficiently infect cells expressing angiotensin-converting enzyme 2
๐ค Moore, Michael J. ๐ค Dorfman, Tatyana ๐ค Li, Wenhui ๐ค Wong, Swee Kee ๐ค Li, Yanhan ๐ค Kuhn, Jens H. ๐ค Coderre, James ๐ค Vasilieva, Natalya ๐ค Han, Zhongchao ๐ค Greenough, Thomas C. ๐ค Farzan, Michael ๐ค Choe, Hyeryun โฐ 2004 ๐ Journal of Virology
- Further characterization of the coronavirus infectious bronchitis virus 3C-like proteinase and determination of a new cleavage site
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ADP-ribose-1โณ-monophosphatase: A conserved coronavirus enzyme that is dispensable for viral replication in tissue culture
๐ค Putics, รkos ๐ค Filipowicz, Witold ๐ค Hall, Jonathan ๐ค Gorbalenya, Alexander E. ๐ค Ziebuhr, John โฐ 2005 ๐ Journal of Virology
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Canine coronavirus induces apoptosis in cultured cells
๐ค Ruggieri, A. ๐ค Di Trani, L. ๐ค Gatto, I. ๐ค Franco, M. ๐ค Vignolo, E. ๐ค Bedini, B. ๐ค Elia, G. ๐ค Buonavoglia, C. โฐ 2007 ๐ Veterinary Microbiology
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Human and bovine coronaviruses recognize sialic acid-containing receptors similar to those of influenza C viruses
๐ค Vlasak, R. ๐ค Luytjes, W. ๐ค Spaan, W. ๐ค Palese, P. โฐ 1988 ๐ Proceedings of the National Academy of Sciences of the United States of America
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Human aminopeptidase N is a receptor for human coronavirus 229E
๐ค Yeager, Curtis L. ๐ค Ashmun, Richard A. ๐ค Williams, Richard K. ๐ค Cardellichio, Christine B. ๐ค Shapiro, Linda H. ๐ค Look, A. Thomas ๐ค Holmes, Kathryn V. โฐ 1992 ๐ Nature
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Structural and biochemical characterization of endoribonuclease nsp15 encoded by middle east respiratory syndrome coronavirus
๐ค Zhang, Lianqi ๐ค Li, Lei ๐ค Yan, Liming ๐ค Ming, Zhenhua ๐ค Jia, Zhihui ๐ค Lou, Zhiyong ๐ค Rao, Zihe โฐ 2018 ๐ Journal of Virology
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Insight into the evolution of nidovirus endoribonuclease based on the finding that nsp15 from porcine Deltacoronavirus functions as a dimer
๐ค Zheng, Anjun ๐ค Shi, Yuejun ๐ค Shen, Zhou ๐ค Wang, Gang ๐ค Shi, Jiale ๐ค Xiong, Qiqi ๐ค Fang, Liurong ๐ค Xiao, Shaobo ๐ค Fu, Zhen F. ๐ค Peng, Guiqing โฐ 2018 ๐ Journal of Biological Chemistry