baez-santos-yahira-m

Keywords

🔗 papain-like protease (67) 🔗 cell lines (125) 🔗 human coronavirus (623) 🔗 cell line (211) 🔗 crystal structure (114) 🔗 severe acute (1373) 🔗 syndrome coronavirus (1074) 🔗 closely related (222) 🔗 significant differences (40) 🔗 respiratory syndrome (2004) 🔗 acute respiratory (1734) 🔗 highly pathogenic (100) 🔗 innate immune (105) 🔗 immune response (314) 🔗 infected cells (307) 🔗 immune responses (142) 🔗 viral replication (258) 🔗 enzymatic activity (29) 🔗 results indicate (178) 🔗 main protease (44)

Articles (6)

X-ray structural and biological evaluation of a series of potent and highly selective inhibitors of human coronavirus papain-like proteases
👤 Báez-Santos, Yahira M. 👤 Barraza, Scott J. 👤 Wilson, Michael W. 👤 Agius, Michael P. 👤 Mielech, Anna M. 👤 Davis, Nicole M. 👤 Baker, Susan C. 👤 Larsen, Scott D. 👤 Mesecar, Andrew D. ⏰ 2014 📚 Journal of Medicinal Chemistry
Catalytic function and substrate specificity of the papain-like protease domain of nsp3 from the middle east respiratory syndrome coronavirus
👤 Báez-Santos, Yahira M. 👤 Mielech, Anna M. 👤 Deng, Xufang 👤 Baker, Susan 👤 Mesecar, Andrew D. ⏰ 2014 📚 Journal of Virology
The SARS-coronavirus papain-like protease: Structure, function and inhibition by designed antiviral compounds
👤 Báez-Santos, Yahira M. 👤 St. John, Sarah E. 👤 Mesecar, Andrew D. ⏰ 2015 📚 Antiviral Research
Deubiquitinating and interferon antagonism activities of coronavirus papain-like proteases
👤 Clementz, Mark A. 👤 Chen, Zhongbin 👤 Banach, Bridget S. 👤 Wang, Yanhua 👤 Sun, Li 👤 Ratia, Kiira 👤 Baez-Santos, Yahira M. 👤 Wang, Jie 👤 Takayama, Jun 👤 Ghosh, Arun K. 👤 Li, Kui 👤 Mesecar, Andrew D. 👤 Baker, Susan C. ⏰ 2010 📚 Journal of Virology
Discovery, synthesis, and structure-based optimization of a series of N -(tert -Butyl)-2-(N -arylamido)-2-(pyridin-3-yl) acetamides (ML188) as potent noncovalent small molecule inhibitors of the severe acute respiratory syndrome coronavirus (SARS-CoV) 3CL protease
👤 Jacobs, Jon 👤 Grum-Tokars, Valerie 👤 Zhou, Ya 👤 Turlington, Mark 👤 Saldanha, S. Adrian 👤 Chase, Peter 👤 Eggler, Aimee 👤 Dawson, Eric S. 👤 Baez-Santos, Yahira M. 👤 Tomar, Sakshi 👤 Mielech, Anna M. 👤 Baker, Susan C. 👤 Lindsley, Craig W. 👤 Hodder, Peter 👤 Mesecar, Andrew 👤 Stauffer, Shaun R. ⏰ 2013 📚 Journal of Medicinal Chemistry
Discovery of N-(benzo[1,2,3]triazol-1-yl)-N-(benzyl)acetamido)phenyl) carboxamides as severe acute respiratory syndrome coronavirus (SARS-CoV) 3CLpro inhibitors: Identification of ML300 and noncovalent nanomolar inhibitors with an induced-fit binding
👤 Turlington, Mark 👤 Chun, Aspen 👤 Tomar, Sakshi 👤 Eggler, Aimee 👤 Grum-Tokars, Valerie 👤 Jacobs, Jon 👤 Daniels, J. Scott 👤 Dawson, Eric 👤 Saldanha, Adrian 👤 Chase, Peter 👤 Baez-Santos, Yahira M. 👤 Lindsley, Craig W. 👤 Hodder, Peter 👤 Mesecar, Andrew D. 👤 Stauffer, Shaun R. ⏰ 2013 📚 Bioorganic and Medicinal Chemistry Letters