tomar-sakshi

Keywords

🔗 severe acute (1373) 🔗 reading frame (222) 🔗 weight loss (41) 🔗 amino acid (454) 🔗 respiratory syndrome (2004) 🔗 acute respiratory (1734) 🔗 cell culture (240) 🔗 epithelial cells (128) 🔗 open reading (215) 🔗 diffuse alveolar (21) 🔗 main protease (44) 🔗 life cycle (63) 🔗 hepatitis virus (437) 🔗 cleavage site (85) 🔗 murine hepatitis (71) 🔗 virus replication (219) 🔗 syndrome coronavirus (1074) 🔗 amino acids (205)

Articles (6)

A mouse model for Betacoronavirus subgroup 2c using a bat coronavirus strain HKU5 variant
👤 Agnihothram, Sudhakar 👤 Yount Jr., Boyd L. 👤 Donaldson, Eric F. 👤 Huynh, Jeremy 👤 Menachery, Vineet D. 👤 Gralinski, Lisa E. 👤 Graham, Rachel L. 👤 Becker, Michelle M. 👤 Tomar, Sakshi 👤 Scobey, Trevor D. 👤 Osswald, Heather L. 👤 Whitmore, Alan 👤 Gopal, Robin 👤 Ghosh, Arun K. 👤 Mesecar, Andrew 👤 Zambon, Maria 👤 Heise, Mark 👤 Denison, Mark R. 👤 Baric, Ralph S. ⏰ 2014 📚 mBio
Discovery, synthesis, and structure-based optimization of a series of N -(tert -Butyl)-2-(N -arylamido)-2-(pyridin-3-yl) acetamides (ML188) as potent noncovalent small molecule inhibitors of the severe acute respiratory syndrome coronavirus (SARS-CoV) 3CL protease
👤 Jacobs, Jon 👤 Grum-Tokars, Valerie 👤 Zhou, Ya 👤 Turlington, Mark 👤 Saldanha, S. Adrian 👤 Chase, Peter 👤 Eggler, Aimee 👤 Dawson, Eric S. 👤 Baez-Santos, Yahira M. 👤 Tomar, Sakshi 👤 Mielech, Anna M. 👤 Baker, Susan C. 👤 Lindsley, Craig W. 👤 Hodder, Peter 👤 Mesecar, Andrew 👤 Stauffer, Shaun R. ⏰ 2013 📚 Journal of Medicinal Chemistry
Targeting zoonotic viruses: Structure-based inhibition of the 3C-like protease from bat coronavirus HKU4 - The likely reservoir host to the human coronavirus that causes Middle East Respiratory Syndrome (MERS)
👤 St. John, Sarah E. 👤 Tomar, Sakshi 👤 Stauffer, Shaun R. 👤 Mesecar, Andrew D. ⏰ 2015 📚 Bioorganic and Medicinal Chemistry
Chimeric exchange of coronavirus nsp5 proteases (3CLpro) identifies common and divergent regulatory determinants of protease activity
👤 Stobart, Christopher C. 👤 Sexton, Nicole R. 👤 Munjal, Havisha 👤 Lu, Xiaotao 👤 Molland, Katrina L. 👤 Tomar, Sakshi 👤 Mesecar, Andrew D. 👤 Denison, Mark R. ⏰ 2013 📚 Journal of Virology
Ligand-induced dimerization of Middle East Respiratory Syndrome (MERS) Coronavirus nsp5 protease (3CLpro): Implications for nsp5 regulation and the development of antivirals
👤 Tomar, Sakshi 👤 Johnston, Melanie L. 👤 John, Sarah E.St 👤 Osswald, Heather L. 👤 Nyalapatla, Prasanth R. 👤 Paul, Lake N. 👤 Ghosh, Arun K. 👤 Denison, Mark R. 👤 Mesecar, Andrew D. ⏰ 2015 📚 Journal of Biological Chemistry
Discovery of N-(benzo[1,2,3]triazol-1-yl)-N-(benzyl)acetamido)phenyl) carboxamides as severe acute respiratory syndrome coronavirus (SARS-CoV) 3CLpro inhibitors: Identification of ML300 and noncovalent nanomolar inhibitors with an induced-fit binding
👤 Turlington, Mark 👤 Chun, Aspen 👤 Tomar, Sakshi 👤 Eggler, Aimee 👤 Grum-Tokars, Valerie 👤 Jacobs, Jon 👤 Daniels, J. Scott 👤 Dawson, Eric 👤 Saldanha, Adrian 👤 Chase, Peter 👤 Baez-Santos, Yahira M. 👤 Lindsley, Craig W. 👤 Hodder, Peter 👤 Mesecar, Andrew D. 👤 Stauffer, Shaun R. ⏰ 2013 📚 Bioorganic and Medicinal Chemistry Letters